TSNAdb v2.0:The Updated Version of Tumor-specific Neoantigen Database  

作　　者：Jingcheng Wu Wenfan Chen Yuxuan Zhou Ying Chi Xiansheng Hua Jian Wu Xun Gu Shuqing Chen Zhan Zhou 

机构地区：[1]Institute of Drug Metabolism and Pharmaceutical Analysis and Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare,Alibaba DAMO Academy,Hangzhou 311121,China [3]The Second Affiliated Hospital of School of Medicine,and School of Public Health,Zhejiang University,Hangzhou 310058,China [4]Innovation Institute for Artificial Intelligence in Medicine,Zhejiang University,Hangzhou 310018,China [5]Department of Genetics,Development and Cell Biology,Iowa State University,Ames,IA 50011,USA

出　　处：《Genomics, Proteomics & Bioinformatics》2023年第2期259-266,共8页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.31971371 and U20A20409);the Key R&D Program of Zhejiang Province,China(Grant No.2020C03010);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(Grant No.LHDMZ22H300002);the AlibabaZhejiang University Joint Research Center of Future Digital Healthcare.

摘　　要：In recent years,neoantigens have been recognized as ideal targets for tumor immunotherapy.With the development of neoantigen-based tumor immunotherapy,comprehensive neoantigen databases are urgently needed to meet the growing demand for clinical studies.We have built the tumor-specific neoantigen database(TSNAdb)previously,which has attracted much attention.In this study,we provide TSNAdb v2.0,an updated version of the TSNAdb.TSNAdb v2.0 offers several new features,including(1)adopting more stringent criteria for neoantigen identification,(2)providing predicted neoantigens derived from three types of somatic mutations,and(3)collecting experimentally validated neoantigens and dividing them according to the experimental level.

关 键 词：NEOANTIGEN Tumor immunotherapy Human leukocyte antigen Somatic mutation DATABASE 

分 类 号：R318[医药卫生—生物医学工程]