NEOANTIGEN

作品数：28被引量：107H指数：6
导出分析报告
相关领域：医药卫生更多>>
相关期刊：《Genomics, Proteomics & Bioinformatics》《Chinese Journal of Cancer Research》《Cancer Innovation》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划World Health Organization中国博士后科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination
《Chinese Medical Journal》2024年第21期2627-2629,共3页Yishan Li Qin Wang Lin Li Shaohua Yuan Hui Chen Rutian Li Fangcen Liu 
supported by the Natural Science Foundation of China(Nos.82203178,82272852,and 82103687);Jiangsu Provincial Key Research and Development Program(No.BE2020619);Natural Science Foundation of Jiangsu Province(No.BK20220191);Nanjing Medical Science and Technology Development Foundation(No.YKK22086).
To the Editor:Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.GISTs mostly occur in the stomach or small intestine among patients around 40-60 years of age,an...
关键词：gastrointestinal STOMACH INTESTINE 
Insights into therapeutic peptides in the cancerimmunity cycle:Update and challenges
《Acta Pharmaceutica Sinica B》2024年第9期3818-3833,共16页Xiaokun Zhang Ye Wu Jiayi Lin Shengxin Lu Xinchen Lu Aoyu Cheng Hongzhuan Chen Weidong Zhang Xin Luan 
the National Natural Science Foundation of China(Nos.82322073,82173846,and 82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009,China);Oriental Scholars of Shanghai Universities(TP2022081,China);China Postdoctoral Science Foundation(No.2021M702215);Jiangxi Province Thousand Talents Program(jxsq2023102168,China);Young Talent Lifting Project of Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Rising-Star Program(No.22QA1409100,China);Shanghai Sailing Program(No.22YF1445000,China);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800,China);Three-Year Action Plan for Three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021-2023)-0208 and ZY(2021-2023)-0401,China];High level Key Discipline of National Administration of Traditional Chinese Medicine(No.zyyzdxk-2023071,China);Innovation Team and Talents Cultivation Program of High level Key Discipline of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004,China);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302,China);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology(China).All figures were created with BioRender.com.
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity ...
关键词：Cancer-immunity cycle Oncolytic peptide Peptide neoantigen vaccine Peptide mimotope Immune checkpoint blockade Cancer immunotherapy Synthetic long peptide vaccine Peptide-major histocompatibility complex 
Neoantigen cancer vaccines:a new star on the horizon
《Cancer Biology & Medicine》2024年第4期274-311,共38页Xiaoling Li Jian You Liping Hong Weijiang Liu Peng Guo Xishan Hao 
supported by grants from the National Clinical Research Center Cancer Fund;the Haihe Laboratory of Synthetic Biology(22HHSWSS00004)。
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells.One of the most exciting advances within th...
关键词：IMMUNOTHERAPY neoantigen cancer vaccine solid tumors high-throughput sequencing BIOINFORMATICS PDOs AI HLA TCR 
抗原改造联合纳米肿瘤疫苗用以克服肿瘤新抗原短缺及在多种肿瘤类型上激起强效抗肿瘤免疫反应被引量：1
《Science Bulletin》2024年第7期922-932,共11页陈宏宇 黄子超 李佳玄 董思 徐玉笛 马胜 赵佳雨 刘丽萍 孙天盟 宋万通 陈学思 
supported by the National Natural Science Foundation of China (22222509, 52025035, 52103194, and 22105199);The Ministry of Science and Technology of China (2022YFE0110200);Bureau of International Cooperation Chinese Academy of Sciences (121522KYSB20200029);Jilin Province Science and Technology Development Plan (YDZJ202101ZYTS131, 20220402037GH, and 20210508049RQ);Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers (20210504001GH);The Youth Innovation Promotion Association of Chinese Academy of Sciences (2020232)。
Neoantigen cancer vaccines have been envisioned as one of the most promising means for cancer therapies.However,identifying neoantigens for tumor types with low tumor mutation burdens continues to limit the effectiven...
关键词：Cancer immunotherapy Cancer vaccine NEOANTIGEN NANOCARRIER Poly(2-oxazoline)s 
NeoHunter:Flexible software for systematically detecting neoantigens from sequencing data
《Quantitative Biology》2024年第1期70-84,共15页Tianxing Ma Zetong Zhao Haochen Li Lei Wei Xuegong Zhang 
National Key R&D Program of China,Grant/Award Number:2021YFF1200900;National Natural Science Foundation of China,Grant/Award Numbers:61721003,62250005,62103227。
Complicated molecular alterations in tumors generate various mutant peptides.Some of these mutant peptides can be presented to the cell surface and then elicit immune responses,and such mutant peptides are called neoa...
关键词：cancer vaccine molecular alteration NEOANTIGEN neoantigen prioritization 
Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope
《Signal Transduction and Targeted Therapy》2023年第11期5417-5428,共12页Bingyu Li Ping Jing Genhui Zheng Chenyu Pi Lu Zhang Zuojing Yin Lijun Xu Jingxuan Qiu Hua Gu Tianyi Qiu Jianmin Fang 
We wish to thank all members of our laboratory for their helpful suggestions and support.This study was supported by grants from the National Natural Science Foundation of China(32370697,31900483);the Shanghai Sailing Program(19YF1441100);the Shanghai Science&Technology Basic Research Program(18JC1414400);the Key Science and Technology Program of Henan Province(212102310872).
Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment.The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing(WGS)and bioinformatic...
关键词：MELANOMA PREDICTION enable 
Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy被引量：1
《Bioactive Materials》2023年第8期169-180,共12页Ting Su Xiang Liu Shuibin Lin Furong Cheng Guizhi Zhu 
G.Z.acknowledges funding support from NIH(R01CA266981,R01AI168684,R35GM143014,R21NS114455);DoD CDMRP Breast Cancer Breakthrough Award Level II(BC210931/P1);NIH-NCATS KL2 scholarship(KL2TR002648)via VCU C.Kenneth and Dianne Wright Center for Clinical and Translational Research(UL1TR002649);American Cancer Society Research Scholar Grant(RSG-22-055-01-IBCD);METAvivor Early Career Investigator Award,among others.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.T.S.and F.C.acknowledge the National Natural Science Foundation of China(52103199,82102203);Guangdong Basic and Applied Basic Research Foundation(2020A1515110811).
Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.Here,we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in...
关键词：Polymeric nanoparticles Combination adjuvants Cancer neoantigen Nanovaccine codelivery Cancer immunotherapy 
TSNAdb v2.0:The Updated Version of Tumor-specific Neoantigen Database
《Genomics, Proteomics & Bioinformatics》2023年第2期259-266,共8页Jingcheng Wu Wenfan Chen Yuxuan Zhou Ying Chi Xiansheng Hua Jian Wu Xun Gu Shuqing Chen Zhan Zhou 
supported by the National Natural Science Foundation of China(Grant Nos.31971371 and U20A20409);the Key R&D Program of Zhejiang Province,China(Grant No.2020C03010);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(Grant No.LHDMZ22H300002);the AlibabaZhejiang University Joint Research Center of Future Digital Healthcare.
In recent years,neoantigens have been recognized as ideal targets for tumor immunotherapy.With the development of neoantigen-based tumor immunotherapy,comprehensive neoantigen databases are urgently needed to meet the...
关键词：NEOANTIGEN Tumor immunotherapy Human leukocyte antigen Somatic mutation DATABASE 
Bottlenecks and opportunities in immunotherapy for glioma:a narrative review
《Journal of Bio-X Research》2022年第4期151-162,共12页Ying Shi Mengwan Wu Yuyang Liu Ling Chen Xiuwu Bian Chuan Xu 
National Natural Science Foundation of China(No.81873048,to CX);Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China(No.ZYGX2021YGCX004,to CX);Sichuan Science and Technology Program(No.2021YFH0187,to YS);Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China(No.ZYGX2021YGCX018,to YS);Fundamental Research Funds for the Central Universities(No.ZYGX2020KYQD002,to YS).
Glioma is the most aggressive brain tumor having invasive ability and a highly heterogeneous phenotype.Many patients with glioma respond poorly to traditional surgery or temozolomide-based chemotherapy.Over the past f...
关键词：chimeric antigen receptor T cells GLIOMA immune checkpoint inhibitor IMMUNOTHERAPY NEOANTIGEN 
Neoantigen vaccine and neoantigen-specific cell adoptive transfer therapy in solid tumors:Challenges and future directions
《Cancer Innovation》2022年第2期168-182,共15页Yanwei Shen Lu Yu Xiaoli Xu Shaojun Yu Zhuo Yu 
National Natural Science Foundation of China,Grant/Award Numbers:81972444,82172566。
The phenomenon of tumor hierarchy and genetic instability can be explained by the“two-hits theory”and results in the occurrence of many somatic mutations.The expression of nonsynonymous mutations results in the prod...
关键词：NEOANTIGEN cancer vaccine IMMUNOTHERAPY tumor microenvironment HETEROGENEITY precision medicine 
全选清除导出
共3页<123>
检索报告 对象比较 聚类工具 使用帮助 返回顶部