CTRR-ncRNA:A Knowledgebase for Cancer Therapy Resistance and Recurrence Associated Non-coding RNAs  

作　　者：Tong Tang Xingyun Liu Rongrong Wu Li Shen Shumin Ren Bairong Shen 

机构地区：[1]Institutes for Systems Genetics,Frontiers Science Centre for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,China [2]West China School of Medicine,Sichuan University,Chengdu 610041,China

出　　处：《Genomics, Proteomics & Bioinformatics》2023年第2期292-299,共8页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.32070671);the regional innovation cooperation between Sichuan and Guangxi Provinces of China(Grant No.2020YFQ0019).

摘　　要：Cancer therapy resistance and recurrence(CTRR)are the dominant causes of death in cancer patients.Recent studies have indicated that non-coding RNAs(ncRNAs)can not only reverse the resistance to cancer therapy but also are crucial biomarkers for the evaluation and prediction of CTRR.Herein,we developed CTRR-ncRNA,a knowledgebase of CTRR-associated ncRNAs,aiming to provide an accurate and comprehensive resource for research involving the association between CTRR and ncRNAs.Compared to most of the existing cancer databases,CTRRncRNA is focused on the clinical characterization of cancers,including cancer subtypes,as well as survival outcomes and responses to personalized therapy of cancer patients.Information pertaining to biomarker ncRNAs has also been documented for the development of personalized CTRR prediction.A user-friendly interface and several functional modules have been incorporated into the database.Based on the preliminary analysis of genotype-phenotype relationships,universal ncRNAs have been found to be potential biomarkers for CTRR.The CTRR-ncRNA is a translation-oriented knowledgebase and it provides a valuable resource for mechanistic investigations and explainable artificial intelligence-based modeling.

关 键 词：Translational bioinformatics Therapeutic resistance Cancer recurrence Non-coding RNA KNOWLEDGEBASE 

分 类 号：R730.51[医药卫生—肿瘤]