干细胞在泪膜为导向型干眼治疗中作用的研究进展  

Advances in the role of stem cells in tear film-oriented therapy for dry eye

作　　者：顾华香 程验 李鹏飞 张国伟 季敏 管怀进[1] GU Huaxiang;CHENG Yan;LI Pengfei;ZHANG Guowei;JI Min;GUAN Huaijin(Medical School of Nantong University,Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学医学院,南通大学附属医院眼科,江苏省南通市226001

出　　处：《眼科新进展》2023年第11期903-906,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助项目(编号:81974129,82171038)。

摘　　要：干眼(DE)是一种以泪膜不稳定为主要特征的多因素慢性疾病,常伴有干涩、异物、视物模糊和视疲劳等临床症状,中重度DE还可导致眼表损伤进而引起视力障碍。目前,DE主要采用人工泪液替代等传统对症治疗方法。近年来,大量科研工作致力于寻找DE的新型疗法,以期修复受损的泪腺、副泪腺、睑板腺和结膜杯状细胞等外分泌腺的结构与功能,继而恢复各层泪液的分泌,维持泪膜的稳定性。干细胞因其多能分化特性已成为再生医学领域重要的种子细胞。由于人眼结构与生理功能的独特性,眼组织再生是再生医学研究最活跃的领域。本文主要围绕干细胞在DE再生治疗中的研究进展进行综述。Dry eye(DE)is a multifactorial chronic disease characterized by tear film instability,often accompanied by dryness,foreign body sensation,blurred vision and visual fatigue.Moderate to severe DE can lead to ocular surface damage and visual impairment.At present,DE is mainly treated according to symptoms,for example,with artificial tear replacement.In recent years,a lot of research has been made to find new DE therapies,which are expected to repair the structure and function of damaged exocrine glands,such as lacrimal glands,accessory lacrimal glands,meibomian glands and conjunctival goblet cells,promote the secretion of tear,and maintain the stability of tear films.Due to their pluripotent differentiation,stem cells have become important seed cells in the field of regenerative medicine.Human eyes are unique in structure and physiological function;thus,eye tissue regeneration is of the most concern in the field of regenerative medicine.This article reviews the latest research on the role of stem cells in DE regenerative therapy.

关 键 词：干眼 泪膜 干细胞 

分 类 号：R777.34[医药卫生—眼科]