巨噬细胞代谢重编程在新生血管性年龄相关性黄斑变性中的作用研究进展  

Research progress on the metabolic reprogramming of macrophages in neovascular age-related macular degeneration

作　　者：李桐栖 孔德平 孙晓东 LI Tongqi;KONG Deping;SUN Xiaodong(Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200071,China;Precision Research Center for Refractory Diseases,Institute for Clinical Research,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201620,China)

机构地区：[1]上海交通大学医学院附属第一人民医院眼科,上海市200071 [2]上海交通大学医学院附属第一人民医院疑难疾病精准研究中心,上海市201620

出　　处：《眼科新进展》2023年第11期920-924,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金(编号:82171076,82101257);上海市科学技术委员会项目(编号:20Z11900400,21YF1436900)。

摘　　要：巨噬细胞是调节组织稳态与修复重塑的关键免疫细胞。在新生血管性年龄相关性黄斑变性(NVAMD)的发展过程中,巨噬细胞对调节脉络膜新生血管至关重要。由于其高可塑性和功能异质性,尚不明确巨噬细胞的调节机制。新近研究发现,代谢重编程是巨噬细胞效应功能调节的关键因素。在脉络膜新生血管的发生发展过程中,巨噬细胞受到微环境刺激及全身因素调节,其代谢途径重新编程,从而显著改变功能表型,影响NVAMD的发生发展。因此,深入了解巨噬细胞促血管新生表型的代谢变化及形成机制,有望为NVAMD治疗提供新靶点。Macrophages are key immune cells that regulate homeostasis,repair and remodeling of tissues.In the development of neovascular age-related macular degeneration(NVAMD),macrophages are essential for regulating choroidal neovascularization(CNV).Macrophages are characterized by high plasticity and functional heterogeneity,and their regulatory mechanism has not been clear.New studies have revealed that metabolic reprogramming is a key factor in regulating the effect and function of macrophages.During the occurrence and development of CNV,macrophages are regulated by microenvironment stimuli and systemic factors,and their metabolic pathways are reprogrammed and significantly alter the phenotype and function,which subsequently affect the occurrence and development of NVAMD.Therefore,an in-depth understanding of the metabolic changes and mechanisms underlying the pro-angiogenic phenotype of macrophages is expected to provide new targets for the treatment of NVAMD.

关 键 词：巨噬细胞 代谢重编程 脉络膜新生血管 

分 类 号：R774.5[医药卫生—眼科]