多不饱和脂肪酸代谢与动脉粥样硬化的关系  

Polyunsaturated fatty acid metabolism and its relationship with atherosclerosis

作　　者：刘秋雷 杨燎[1] 刘硕[1] 王盛[1] LIU Qiuli;YANG Liao;LIU Shuo;WANG Sheng(Departmengt of Vascular Surgery Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100011,China)

机构地区：[1]首都医科大学附属北京安贞医院血管外科中心,北京市100011

出　　处：《中国动脉硬化杂志》2023年第10期891-900,共10页Chinese Journal of Arteriosclerosis

基　　金：北京市科委基金项目(Z191100008319010);首都医科大学附属北京安贞医院院内课题(PX2017016)。

摘　　要：动脉粥样硬化是多因素共同作用引起的,其发病机制复杂,目前尚未完全阐明。多不饱和脂肪酸作为脂肪酸家族中的一员,是哺乳动物生长发育的关键营养物质,其摄入种类和摄入量以及脂肪酸去饱和酶均能影响动脉粥样硬化性疾病的进程。脂肪酸去饱和酶基因簇能够调控脂肪酸去饱和酶的活性并进一步影响动脉粥样硬化。基于代谢和遗传学的观点,本文综述了多不饱和脂肪酸在脂肪酸去饱和酶的调节下对动脉粥样硬化影响的研究进展,并总结了脂肪酸去饱和酶基因簇变异与动脉粥样硬化性心血管疾病之间的关系。Multiple factors cause atherosclerosis,and its pathogenesis is complex and has not been fully elucidated.Polyunsaturated fatty acids,a member of the fatty acid family,are critical nutrients for mammalian growth and development.Types and intakes of polyunsaturated fatty acids,and fatty acid desaturase can affect the course of atherosclerotic disease.Fatty acid desaturase gene cluster can regulate fatty acid desaturase activity and further affect atherosclerosis.Based on the metabolic and genetic perspectives,this article reviewed the research progress of the effects of polyunsaturated fatty acids on atherosclerosis regulated by fatty acid desaturase and the relationship between genetic variants of the fatty acid desaturase gene cluster and atherosclerotic cardiovascular disease was summarized.

关 键 词：动脉粥样硬化 多不饱和脂肪酸 脂肪酸去饱和酶基因簇 脂肪酸去饱和酶 

分 类 号：R543.5[医药卫生—心血管疾病]