光生物调节在管理抗肿瘤治疗毒性中的研究进展  

Photobiomodulation for Management of Toxicity Induced by Anticancer Therapy:State of the Art

作　　者：李莹[1] 胡德胜[1] 谭文勇 LI Ying;HU Desheng;TAN Wenyong(Department of Radiation Oncology,Hubei Cancer Hospital,Wuhan 430079,China;Department of Oncology,Shenzhen Hospital,Nanfang Medical University,Shenzhen 518101,China)

机构地区：[1]湖北省肿瘤医院放疗科,武汉430079 [2]南方医科大学深圳医院肿瘤科,深圳518101

出　　处：《肿瘤防治研究》2023年第10期1004-1009,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81974462,81974362);南方医科大学深圳医院临床研究启动计划(LCJH202003)。

摘　　要：光生物调节治疗(photobiomodulation therapy,PBMT)是利用红光或近红外光治愈、恢复和刺激生理的过程,从而修复创伤和(或)疾病所造成的损伤。PBMT广泛用于运动损伤、关节炎、神经性疼痛、背部和颈部疼痛等。近年来,PBMT作为癌症治疗相关不良反应的安全有效手段,如头颈部肿瘤放化疗患者或干细胞移植患者的口腔黏膜炎、放疗相关性口干、味觉障碍、放射性皮炎、放疗后纤维化和头颈部肿瘤及乳腺癌相关的淋巴水肿等。但PBMT的设备和最佳剂量学参数尚未完全明确,仍需进一步探索。Photobiomodulation therapy(PBMT)is the use of red or near-infrared light to heal,restore,and stimulate physiological processes that repair damage caused by trauma or a disease.PBMT is widely used in sports injuries,arthritis,neuropathic pain,and back and neck pain.In recent years,PBMT is a safe and effective tool for toxic reactions associated with cancer treatment,such as oral mucositis in patients undergoing chemo-radiotherapy for head and neck cancer or stem cell transplantation,radiation-associated dry mouth,taste disorders,radiation dermatitis,post-radiotherapy fibrosis,and lymphedema associated with head and neck cancer and breast cancer.However,the equipment and optimal dosimetric parameters for PBMT have not been fully defined and need to be further explored.

关 键 词：光生物调节治疗 抗肿瘤治疗 放疗 化疗 不良反应 

分 类 号：R730.6[医药卫生—肿瘤]