降眼压药物对青光眼患者眼表影响的研究进展  

Research progress in the effects of intraocular pressure-lowering drugs on the ocular surface of glaucoma patients

作　　者：杨洁 何媛[2] 刘瀛[2] 石蕊[3] 卢瑶[1,3] 刘丹丹 龚小羽 Jie Yang;Yuan He;Ying Liu;Rui Shi;Yao Lu;Dan-Dan Liu;Xiao-Yu Gong(Xi'an Medical University,Xi'an 710021,Shaanxi Province,China;Department of Ophthalmology,the Second Affiliated Hospital of Xi'an Medical University,Xi'an 710038,Shaanxi Province,China;Department of Ophthalmology,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi Province,China)

机构地区：[1]西安医学院,中国陕西省西安市710021 [2]西安医学院第二附属医院眼科,中国陕西省西安市710038 [3]陕西省人民医院眼科,中国陕西省西安市710068

出　　处：《国际眼科杂志》2023年第11期1826-1830,共5页International Eye Science

基　　金：西安医学院第二附属医院2022年度院级课题(No.22KY0111)。

摘　　要：青光眼是一种累及视网膜神经节细胞的慢性视神经病变,以视乳头萎缩、视野缺损及视力下降为共同特征的疾病。由于青光眼是一种慢性疾病,长期滴用局部降眼压药物往往会合并眼表疾病,从而降低药物依从性,最终影响治疗效果。目前局部降眼压药物主要有前列腺素类衍生物、β-肾上腺素能受体阻滞剂、α-肾上腺素能受体激动剂、局部碳酸酐酶抑制剂、拟胆碱能类药物。本文就以上5种降眼压药物对青光眼患者眼表影响和相关机制做一综述,并为青光眼患者的眼表保护提供预防性措施。Glaucoma is a chronic optic neuropathy that affects the retinal ganglion cells,characterized by optic disc atrophy,visual field defects,and visual acuity loss.Since glaucoma is a chronic disease,long-term use of topical intraocular pressure-lowering medications often leads to ocular surface diseases,thus reducing medication adherence and ultimately affecting treatment efficacy.Currently,topical intraocular pressure-lowering medications include prostaglandin derivatives,β-adrenergic blockers,α-adrenergic agonists,topical carbonic anhydrase inhibitors,and cholinergic drugs.This article provides a comprehensive review of the effects and related mechanisms of these five antiglaucoma medications on the ocular surface of glaucoma patients and offers preventative measures for the protection of ocular surface in glaucoma patients.

关 键 词：局部降眼压药物 青光眼 眼表疾病 

分 类 号：R775[医药卫生—眼科]