遗传综合征致儿童自身免疫性甲状腺疾病易感的相关研究进展  

Research progress of susceptibility to autoimmune thyroid diseases in children caused by genetic syndrome

作　　者：罗丹(综述) 梁丽俊(审校)[2] LUO Dan(reviewing);LIANG Lijun(checking)(Department of Clinical Medicine,Ningxia Medical University,Yinchuan 750004,Ningxia,China;Department of Pediatrics,General Hospital of Ningxia Medical University,Yinchuan 750003,Ningxia,China)

机构地区：[1]宁夏医科大学临床医学院,银川750004 [2]宁夏医科大学总医院儿科,银川750003

出　　处：《医学研究与战创伤救治》2023年第6期667-672,共6页Journal of Medical Research & Combat Trauma Care

摘　　要：自身免疫性甲状腺疾病(AITD)是儿童时期最常见的获得性甲状腺疾病,AITD可以单独发生,也可以与特定遗传综合征同时出现,且特定遗传综合征的背景下(如唐氏综合征、22q11.2缺失综合征、Klinefelter综合征等),儿童AITD的发病率明显升高。现就儿童特定遗传综合征中AITD流行病学、临床特征进行综述,并探究遗传综合征与自身免疫性疾病易感之间的内在联系及可能机制,为建立遗传综合征中自身免疫相关疾病的早期防治策略提供理论和实践依据。Autoimmune thyroid disease(AITD)is the most common acquired thyroid disease in childhood.AITD can occur alone or in conjunction with other autoimmune diseases.In the context of specific genetic syndromes(such as Down syndrome,22q11.2 deletion syndrome,Klinefelter syndrome,etc.),the incidence of autoimmune thyroid diseases in children is significantly higher.This article reviewed the epidemiology and clinical characteristics of autoimmune thyroid diseases in children with specific genetic syndromes,and explored the internal correlation and possible mechanism between genetic syndromes and susceptibility to autoimmune diseases,providing atheoretical and practical basis for the establishment of early prevention and treatment strategies of autoimmune related diseases in genetic syndromes.

关 键 词：儿童 遗传综合征 自身免疫性甲状腺疾病 

分 类 号：R581[医药卫生—内分泌]