氟维司群联合阿贝西利治疗HR阳性晚期乳腺癌的效果  

Effect of Fulvestrant Combined with Abemaciclib in the Treatment of HR Positive Advanced Breast Cancer

作　　者：李明浩 何伟 邱晶晶[1] 芮坤 LI Minghao;HE Wei;QIU Jingjing;RUI Kun(Taixing People's Hospital,Taixing 225400,China;不详)

机构地区：[1]泰兴市人民医院,江苏泰兴225400

出　　处：《中外医学研究》2023年第29期53-56,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨氟维司群联合阿贝西利治疗激素受体(HR)阳性晚期乳腺癌的效果。方法:选取2021年5月—2022年5月泰兴市人民医院收治的80例HR阳性晚期乳腺癌患者。根据随机数表法将其分为观察组及对照组,各40例。对照组给予氟维司群治疗,观察组在对照组基础上给予阿贝西利。比较两组近期疗效,中位随访时间,治疗前后免疫功能,不良反应。结果:观察组客观缓解率(ORR)、疾病控制率(DCR)均高于对照组,差异有统计学意义(P<0.05)。观察组中位随访时间长于对照组。治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均显著升高,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氟维司群联合阿贝西利治疗HR阳性晚期乳腺癌可提高近期效果,改善患者免疫功能,且不会增加不良反应,安全有效。Objective:To investigate the effects of Fulvestrant combined with Abemaciclib in the treatment of hormone receptor(HR)positive advanced breast cancer.Method:A total of 80 HR positive patients with advanced breast cancer admitted to Taixing People's Hospital from May 2021 to May 2022 were selected.They were divided into observation group and control group according to random number table method,with 40 cases in each group.The control group was given Fulvestrant treatment,and the observation group was given Abemaciclib on the basis of the control group.The short term efficacy,follow up time,immune function before and after treatment,adverse reactions were compared between the two groups.Result:The objective response rate(ORR)and disease control rate(DCR)of observation group were higher than those of control group,and the differences were statistically significant(P<0.05).The follow up time in the observation group was longer than that in the control group.After treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were significantly increased in both groups,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Fulvestrant combined with Abemaciclib in the treatment of HR positive advanced breast cancer can improve the short term effect,improve the immune function of patients,and does not increase the adverse effects,which is safe and effective.

关 键 词：激素受体阳性 乳腺癌 阿贝西利 免疫功能 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]