凝血功能检测在脑出血患者预后评估中的应用价值  

Application Value of Coagulation Function Testing in Prognostic Evaluation of Patients with Cerebral Hemorrhage

作　　者：李健[1] 禇荣涛 张志越[1] 龚铭杰[1] LI Jian;CHU Rongtao;ZHANG Zhiyue;GONG Mingjie(Neurosurgery Department,Changshu City the Second People's Hospital,Changshu,Jiangsu 215500)

机构地区：[1]常熟市第二人民医院神经外科,江苏常熟215500

出　　处：《智慧健康》2023年第19期101-104,共4页Smart Healthcare

摘　　要：目的探究凝血功能在不同预后脑出血患者间的差异及预测脑出血预后的价值分析。方法选取2017年4月-2022年4月本院接受治疗且预后不同的患者中,共纳入130例研究对象,根据预后效果不同,分为预后理想组以及预后不良组,每组各65例,并分析两组患者间的凝血指标差异。结果预后理想组的D-二聚体(0.83±0.16)mg/L、抗凝血酶(174.27±16.68)mg/L、活化部分凝血活酶时间(45.91±8.26)s、凝血酶原时间为(16.50±2.31)s,预后不良组的D-二聚体(0.53±0.11)mg/L、抗凝血酶(293.10±23.45)mg/L、活化部分凝血活酶时间(29.91±7.34)s、凝血酶原时间为(13.01±3.51)s,两组间的差异具有显著统计学意义(P<0.05);且以四种凝血指标作为脑血栓预后风险因素的回归分析中呈现显著统计学意义(P<0.05)。结论凝血功能指标在不同脑出血预后患者中存在显著的差异,以凝血功能各个指标作为预测脑出血预后的危险因素可以实现对脑出血预后的预测,具有显著的预测价值,因此对脑出血患者的凝血功能动态的监测,对脑出血的诊疗和预后促进以及临床诊疗措施的开展具有理想的预测价值,值得在临床中推广应用。Objective To explore difference in coagulation function of patients with different prognosis of cerebral hemorrhage and analyze value of predicting prognosis of cerebral hemorrhage.Methods The paper included 130 patients with different prognosis in our hospital from April 2017 to April 2022 based on inclusion and exclusion criteria designed for the study,and divided them into ideal prognosis group and poor prognosis group according to different prognosis effect,and analyzed difference in coagulation indicators between two groups.Results D-dimer was(0.83±0.16)mg/L,antithrombin was(174.27±16.68)mg/L,activated partial thromboplastin time was(45.91±8.26)s,prothrombin time was(16.50±2.31)s in ideal prognosis group,and D-dimer was(0.53±0.11)mg/L,antithrombin was(293.10±23.45)mg/L,activated partial thromboplastin time was(29.91±7.34)s and prothrombin time was(13.01±3.51)s in poor prognosis group,with significant difference between two groups(P<0.05).Regression analysis with prognostic risk factors of four coagulation indicators for cerebral thrombosis showed significant statistical significance(P<0.05).Conclusion There was significant difference in coagulation function indicators of patients with different prognosis of cerebral hemorrhage.Predicting prognosis of cerebral hemorrhage with risk factors of coagulation function indicators can achieve significant predictive value.Therefore,monitoring dynamic coagulation function of patients with cerebral hemorrhage can achieve ideal predictive value for diagnosis,treatment,prognosis promotion and clinical diagnosis and treatment measures,which is worthy of promotion and application in clinical practice.

关 键 词：凝血功能检测 脑出血 预后 风险因素 

分 类 号：R743.34[医药卫生—神经病学与精神病学]