Ⅰ~Ⅱ期老年肺癌患者ALDH1、CA21-1、HMGA2表达与术后远期预后的关系  

Relationship Between ALDH1,CA21-1,HMGA2 and Postoperative Long-term Prognosis in Elderly Patients with Stage Ⅰ-Ⅱ Lung Cancer

作　　者：曹峰[1] 栾加强 蔡祖勋[1] 钱如林[1] CAO Feng;LUAN Jiaqiang;CAI Zuxun(Henan Provincial Chest Hospital,Zhengzhou,450000)

机构地区：[1]河南省胸科医院,郑州大学附属胸科医院,450000

出　　处：《实用癌症杂志》2023年第11期1773-1776,共4页The Practical Journal of Cancer

摘　　要：目的 检测Ⅰ~Ⅱ期老年非小细胞肺癌(NSCLC)患者术后血清乙醛脱氢酶1(ALDH1)、细胞角蛋白片段19片段抗原21-1(CA21-1)及高迁移率族蛋白A2(HMGA2)的水平,并探讨与其预后的关系。方法 收集行根治性手术治疗的78例Ⅰ~Ⅱ期老年NSCLC患者,分别于术前、术后采集静脉血,检测血清ALDH1、CA21-1、HMGA2水平;所有患者随访5年,分析术后血清ALDH1、CA21-1、HMGA2水平与NSCLC患者临床病理特征及预后的关系。结果 术后,患者血清ALDH1、CA21-1和HMGA2均较术前显著降低(P<0.05);患者术后血清ALDH1、CA21-1和HMGA2水平与肿瘤分期、淋巴结转移有关(P<0.05),即肿瘤分期越晚、合并淋巴结转移者术后血清ALDH1、CA21-1和HMGA2水平越高;Kaplan-Meier生存分析显示:高CA21-1组整体生存情况较低CA21-1水平组差(P<0.05),高HMGA2水平组整体生存情况较低HMGA2水平组差(P<0.05),高ALDH1水平组与低ALDH1水平组整体生存情况比较无显著差异(P>0.05);COX多因素回归分析结果表明:年龄≥70岁、肿瘤分期Ⅱ期、合并淋巴结转移、高CA21-1水平、高HMGA2水平是Ⅰ~Ⅱ期老年肺癌患者术后5年生存率的独立危险因素(P<0.05)。结论 老年肺癌患者术后高血清ALDH1、CA21-1、HMGA2水平与肿瘤分期晚、合并淋巴结转移有关,其中高CA21-1、HMGA2水平是术后远期生存率的独立危险因素。Objective To detect levels of serum acetaldehyde dehydrogenase 1(ALDH1),cytokeratin fragment 19(CA21-1)and high mobility group protein A2(HMGA2)in elderly patients with stageⅠ~Ⅱnon-small cell lung cancer(NSCLC),and to explore their relationship with postoperative long-term prognosis.Methods A total of 78 elderly patients with stage I-II NSCLC underwent radical surgery were enrolled.Before and after surgery,venous blood was collected to detect serum ALDH1,CA21-1 and HMGA2 levels.All patients were followed up for 5 years.The relationship between serum ALDH1,CA21-1,HMGA2 and clinicopathological characteristics,prognosis was analyzed.Results After surgery,levels of serum ALDH1,CA21-1 and HMGA2 were significantly decreased(P<0.05),and which were correlated with tumor staging and lymph node metastasis(P<0.05).Th levels of serum ALDH1,CA21-1 and HMGA2 were higher in patients with higher tumor staging and lymph node metastasis.Kaplan-Meier survival analysis showed that overall survival status in high CA21-1 group was worse than that in low CA21-1 group(P<0.05).The overall survival status in high HMGA2 group was worse than that in low HMGA2 group(P<0.05).There was no significant difference in overall survival status between high ALDH1 group and low ALDH1 group(P>0.05).The results of COX multivariate regression analysis showed that age≥70 years,tumor staging at stage II,lymph node metastasis,high levels of CA21-1 and HMGA2 were independent risk factors of survival(P<0.05).Conclusion High levels of serum ALDH1,CA21-1 and HMGA2 are correlated with high tumor staging and lymph node metastasis in elderly patients with lung cancer.High levels of CA21-1 and HMGA2 are independent risk factors of postoperative long-term survival.

关 键 词：肺癌 根治术 乙醛脱氢酶1 细胞角蛋白片段19片段抗原21-1 高迁移率族蛋白A2 预后 

分 类 号：R734.2[医药卫生—肿瘤]