宫颈癌患者癌组织中IL-33的表达及其与预后的相关性  

Expression of IL-33 in Cervical Cancer Tissues and Its Correlation with Prognosis

作　　者：李静 岳红[1] LI Jing;YUE Hong(Hanzhong Central Hospital,Hanzhong,723000)

机构地区：[1]陕西省汉中市中心医院,723000

出　　处：《实用癌症杂志》2023年第11期1813-1816,共4页The Practical Journal of Cancer

摘　　要：目的 探讨白介素-33(IL-33)在宫颈癌患者癌组织中的表达情况及其与临床病理特征、预后的联系。方法 选取102例宫颈癌患者,于手术期间,采集所有患者的癌组织与癌旁正常组织标本,将其分别纳入癌组织组和癌旁组织组,以免疫组化法检测2组的IL-33表达水平,分析IL-33与宫颈癌患者的临床病理特征关系。随访3年,以Kaplan-Meier法分析IL-33表达与宫颈癌患者生存率的关系。结果 癌组织组IL-33中度阳性[41.18%(42/102)]与强阳性占比[30.39%(31/102)]高于癌旁组织组(0.00%、0.00%),阴性[8.82%(9/102)]、弱阳性[19.61%(20/102)]占比低于癌旁组织组[60.78%(62/102)、39.22%(40/102)],有统计学差异(P<0.05)。IL-33表达与宫颈癌患者年龄、产次、肿瘤大小、组织学类型无关(P>0.05),与分化程度、肌层浸润深度、国际妇产科联盟(FIGO)分期、淋巴结转移有关(P<0.05)。Kaplan-Meier结果显示:IL-33高表达宫颈癌患者的3年生存率[39.72%(29/73)]低于低表达患者[62.07%(18/29)],有统计学差异(P<0.05)。结论 宫颈癌患者癌组织中IL-33呈高表达水平,其表达与分化程度、肌层浸润深度、FIGO分期等联系紧密,且IL-33表达水平越高,患者3年生存率越低,其预后越差。Objective To investigate the expression of interleukin-33(IL-33)in cervical cancer tissues and its relationship with clinical pathological features and prognosis.Methods 102 patients with cervical cancer were selected.During the surgery period,cancer tissue and normal adjacent tissue samples were collected from all patients,and they were included in the cancer tissue group and adjacent tissue group,respectively.The expression level of IL-33 in both groups was detected using immunohistochemistry,and the relationship between IL-33 and clinical pathological characteristics of cervical cancer patients was analyzed.Follow up for 3 years and analyze the relationship between IL-33 expression and survival rate of cervical cancer patients using Kaplan Meier method.Results The proportion of IL-33 moderately positive[41.18%(42/102)]and strongly positive[30.39%(31/102)]in the cancer tissue group was higher than that in the adjacent tissue group[0.00%,0.00%],and the proportion of negative[8.82%(9/102)]and weakly positive[19.61%(20/102)]was lower than that in the adjacent tissue group[60.78%(62/102),39.22%(40/102)],with statistical differences(P<0.05).The expression of IL-33 was not associated with age,parity,tumor size,and histological type of cervical cancer patients(P>0.05),but with differentiation degree,depth of myometrial invasion,FIGO staging,and lymph node metastasis(P<0.05).The Kaplan Meier results showed that the 3-year survival rate of patients with high IL-33 expression in cervical cancer[39.72%(29/73)]was lower than that of patients with low IL-33 expression[62.07%(18/29)],with a statistical difference(P<0.05).Conclusion IL-33 is highly expressed in cervical cancer tissues,and its expression is closely related to differentiation degree,depth of myometrial invasion,and FIGO staging.The higher the IL-33 expression level,the lower the 3-year survival rate of patients and the poorer their prognosis.

关 键 词：宫颈癌 癌组织 标本 生存率 预后 

分 类 号：R737.33[医药卫生—肿瘤]