老年早期胃癌淋巴结转移规律及其预后  

Law and Prognosis of Lymph Node Metastasis in Early Gastric Cancer in Old Age

作　　者：胡德升 高磊 杨松鹏 刘栋 HU Desheng;GAO Lei;YANG Songpeng(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学附属郑州中心医院,450000

出　　处：《实用癌症杂志》2023年第11期1864-1867,共4页The Practical Journal of Cancer

摘　　要：目的分析老年早期胃癌(EGC)淋巴结转移(LNM)规律及其预后。方法回顾性分析EGC患者98例的临床资料,按照有无LNM分为LNM组(n=19)和非LNM组(n=79)。采用自制调查问卷收集患者年龄、性别、肿瘤部位、组织学分型、浸润程度等资料,分析老年EGC患者LNM的规律及与预后的关系。结果肿瘤直径、组织学分型、浸润程度是影响老年EGC患者发生LNM的单因素(P<0.05);logistic回归分析显示,肿瘤直径>2 cm、组织学分型为分化不良、浸润程度为黏膜下是老年EGC患者发生LNM的危险因素(P<0.05);LNM组患者5年生存率[68.42%(13/19)]较非LNM组[91.14%(72/79)]低(P<0.05);肿瘤直径、组织学分型、浸润程度、LNM是影响老年EGC患者预后的单因素(P<0.05);logistic回归分析显示,肿瘤直径>2 cm、组织学分型为分化不良、浸润程度为黏膜下、有LNM是老年EGC患者预后不良的危险因素(P<0.05)。结论老年EGC患者发生LNM的影响因素较多,肿瘤直径、组织学分型、浸润程度等因素具有可能导致LNM,造成患者预后不良,降低其生存率,临床应根据相关危险因素手术方案和手术范围,改善患者预后。Objective To analyze the pattern and prognosis of lymph node metastasis(LNM)in elderly early gastric cancer(EGC).Methods A retrospective analysis was conducted on the clinical data of 98 EGC patients,who were divided into LNM group(n=19)and non LNM group(n=79)based on the presence or absence of LNM.A self-made survey questionnaire was used to collect data on patient age,gender,tumor location,histological classification,and degree of infiltration,and to analyze the pattern of LNM in elderly EGC patients and its relationship with prognosis.Results The results showed that tumor diameter,histological type,and degree of infiltration were single factors affecting the occurrence of LNM in elderly EGC patients(P<0.05);Logistic regression analysis showed that tumor diameter>2 cm,histological classification as poorly differentiated,and infiltration degree as submucosal were risk factors for LNM in elderly EGC patients(P<0.05);The 5-year survival rate of patients in the LNM group[68.42%(13/19)]was lower than that in the non LNM group[91.14%(72/79)](P<0.05);Tumor diameter,histological classification,degree of infiltration,and LNM are univariate factors that affect the prognosis of elderly EGC patients(P<0.05);Logistic regression analysis showed that tumor diameter>2 cm,histological classification as poorly differentiated,infiltration as submucosal,and presence of LNM were risk factors for poor prognosis in elderly EGC patients(P<0.05).Conclusion There are many influencing factors for the occurrence of LNM in elderly EGC patients.Factors such as tumor diameter,histological classification,and degree of infiltration may lead to LNM,leading to poor prognosis and reduced survival rate.Clinical practice should improve the patient's prognosis based on relevant risk factors,surgical plans,and surgical scope.

关 键 词：早期胃癌 老年 淋巴结转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]