NSCLC患者术后放疗发生SRILT的危险因素分析  

Risk Factors Analysis of 41 Patients with Srilt After Postoperative Radiotherapy for NSCLC

作　　者：韦健健 解玉东 韩丽丽[1] 杨贤 庞晶 岳颖 WEI Jianjian;XIE Yudong;HAN Lili(Zhoukou Central Hospital,Zhoukou,466000)

机构地区：[1]河南省周口市中心医院,466000

出　　处：《实用癌症杂志》2023年第11期1885-1887,共3页The Practical Journal of Cancer

摘　　要：目的分析非小细胞肺癌(NSCLC)患者术后放疗发生放疗相关肺毒性(SRILT)的危险因素。方法选择41例NSCLC术后放疗发生SRILT的患者,并选取同期NSCLC术后放疗后未发生SRILT的41例进行对比研究。分析两组患者的肺功能指标及患者放射剂量与SRILT发生的相关性。结果观察组患者的FEV1显著低于对照组(P<0.05);观察组患者的放射总剂量≥47.5 Gy、V20≥20%、V5为40%~60%及MLD≥10 Gy等占比均显著高于对照组(P<0.05)。结论NSCLC患者接受放疗后,会显著降低SRILT发生率,值得在临床被广泛推广及应用。Objective To analyze the risk factors of symptomatic radiation-induced lung toxicity(SRILT)in patients with non-small cell lung cancer(NSCLC)after radiotherapy.Methods 41 NSCLC patients with SRILT after radiotherapy were selected,and 41 patients without SRILT after radiotherapy in NSCLC during the same period were selected for comparative study.The correlation of lung function index and radiation dose with SRILT occurrence in the 2 groups was analyzed.Results The FEV1 of the observation group was significantly lower than that of the control group(P<0.05).The total dose≥47.5 Gy,V20≥20%,40%~60%V5 and MLD≥10 Gy in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Radiotherapy can significantly reduce the incidence of SRILT in patients with NSCLC,which is worthy of being widely promoted and applied in clinic.

关 键 词：非小细胞癌 放射治疗 风险因素 放疗相关肺毒性 

分 类 号：R734.2[医药卫生—肿瘤]