祛风止动方联合利培酮治疗抽动障碍的随机对照临床研究  

Randomized controlled clinical study on Qufeng Zhidong recipe combined with risperidone in treatment of tic disorder

作　　者：赵欣[1] 朱鹏程[1] 吴敏[1] ZHAO Xin;ZHU Pengcheng;WU Min(Department of Traditional Chinese Medicine,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院中医科,上海200092

出　　处：《教育生物学杂志》2023年第5期384-388,共5页Journal of Bio-education

基　　金：上海市中医药事业发展三年行动计划项目(ZY3-LCPT-2-2005)。

摘　　要：目的研究祛风止动方联合利培酮治疗抽动障碍的临床疗效及安全性。方法采用随机对照设计方法,将300例中、重度抽动障碍患儿分为中药组(祛风止动方)、中西医结合组(祛风止动方+利培酮)和西药组(利培酮),治疗24周。分别于治疗后2、4、8、12、24周时进行随访,采用耶鲁综合抽动严重程度量表(Yale global tic severity scale,YGTSS)和中医证候量表评估治疗效果,记录不良反应的发生情况。结果治疗后24周随访时:依据YGTSS减分率计算总有效率,中药组、中西医结合组和西药组分别为91.0%、94.2%和84.4%,西药组与中西医结合组比较差异有统计学意义(P<0.05);不良反应发生率,中药组为4.50%、中西医结合组为0,西药组为7.78%,组间比较差异有统计学意义(P<0.05)。结论祛风止动方联合利培酮治疗抽动障碍的临床疗效良好,且无明显不良反应。Objective To clarify the clinical efficacy and safety of Qufeng Zhidong recipe combined with risperidone in thetreatment of tic disorder(TD).Methods A total of 300 children with moderate and severe TD were randomly divided into traditional Chinese medicine group(Qufeng Zhidong recipe),integrated medicine group(Qufeng Zhidong recipe and risperidone),and westernmedicine group(risperidone).The patients were treated for 24 weeks,and were followed up at 2,4,8,12,and 24 weeks after treatment.The total effective rates were scored by using Yale global tic severity scale(YGTSS)and traditional Chinese medicine syndrome scale,and side effects were evaluated at each follow-up time.Results After 24 weeks of treatment,the total effective rates of YGTSS were 91.0%in the traditional Chinese medicine group,94.2%in the integrated medicine group,and 84.4%in the western medicine group,respectively.There were significant differences between integrated medicine group and western medicine group(P<0.05).After the 24 weeks’follow-up,the incidence rates of side effects were 4.50%in the Chinese medicine group,0 in the integrated medicinegroup,and 7.78%in the western medicine group,respectively.There were significant differences among the three groups(P<0.05).Conclusion The integrated Qufend Zhidong recipe and risperidone treatment has a good curative effect on TD with low side effects.

关 键 词：抽动障碍 祛风止动方 利培酮 随机对照 临床研究 

分 类 号：R749.94[医药卫生—神经病学与精神病学]