佳木斯地区新生儿重症监护室耐碳青霉烯类肠杆菌科细菌的主动筛查及感染分析  

Active screening and infection analysis of carbapenem resistant enterobacteriaceae bacteria in neonatal intensive care unit in Jiamusi area

作　　者：黄昕明[1] 张舒越 谭盛玉 陈冰 赵博 王勇[2] HUANG Xin-ming;ZHANG Shu-yue;TAN Sheng-yu;CHEN Bing;ZHAO Bo;WANG Yong(Jiamusi Maternal and Child Health Hospital,Jiamusi 154002,China;The First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China)

机构地区：[1]佳木斯市妇幼保健院,黑龙江佳木斯154002 [2]佳木斯大学附属第一医院,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2023年第5期11-13,共3页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省卫生健康委科研课题,编号:2020-352。

摘　　要：目的:分析佳木斯地区CRE的主动筛查在NICU患儿感染防控与治疗中的作用。方法:对2019年10月1日至2020年9月30日收治入本院在NICU住院的患儿,采集全血、脐分泌物、咽拭子、直肠拭子等标本,进行细菌显色培养,检出病原菌进行药敏实验、β-内酰胺酶检测、检出的CRE菌株进行PCR技术及凝胶电泳分析等方法进行检测,应用统计软件SPSS26.0进行数据分析(χ^(2)检验)。结果:经统计学分析发现:日龄≤2d和8~28d细菌分离率差异同样有显著性(χ^(2)=20.86,P<0.002);日龄≤2d和3~7d细菌分离率差异有显著性(χ^(2)=9.54,P<0.002);日龄3~7d及8~28d新生儿的细菌分离率差异无显著性(χ^(2)=0.148,P>0.05)。结论:3d以上的新生儿,特别是羊水吸入、发热新生儿等,可以作为主动筛查对象;本地区新生儿CRE的主要耐药机制是产KPC酶。Objective:To analyze the role of active screening for carbapenem-resistant enterobacteriaceae(CRE)in the prevention and treatment of infections in neonatal intensive care unit(NICU)patients in Jiamusi area.Methods:From October 1,2019,to September 30,2020,samples including whole blood,umbilical secretion,pharyngeal swabs,rectal swabs,etc.,were collected from hospitalized infants in the NICU.Bacterial cultures were performed,and the isolated pathogens were subjected to antimicrobial susceptibility testing,β-lactamase detection,PCR analysis,and gel electrophoresis for CRE strains.Statistical analysis was conducted using SPSS 26 software(χ^(2) test).Results:Statistical analysis revealed significant differences in the isolation rates of bacteria between age groups≤2 days and 8~28 days(χ^(2)=20.86,P<0.002)and between age groups≤2 days and 3~7 days(χ^(2)=9.54,P<0.002).However,there was no significant difference in the bacterial isolation rate between age groups 3~7 days and 8~28 days(χ^(2)=0.148,P>0.05).Conclusion:Infants over 3 days old,especially those with meconium aspiration syndrome or fever,can be actively screened.The main resistance mechanism of CRE in our region is the production of KPC enzymes.

关 键 词：NICU CRE 主动筛查 医院感染 

分 类 号：R511[医药卫生—内科学]