四生散合止痉散加味治疗风痰瘀络型偏头痛患者疗效及对血清MDA、NO水平的影响  

Efficacy of Modified Sisheng Powder with Zhijing Powder in Treating Patients with Migraine of Wind Phlegm Stasis Collaterals Syndrome and Its Influence on Serum MDA and NO Levels

作　　者：王明霞 黄宗文 卢茜 蔡雪峰[4] WANFG Mingxia;HUANG Zongwen;LU Qian(Department of Psychiatry and Geriatry,Hainan Provincial Anning Hospital,Haikou Hainan 570100,China;Department of Traditional Chinese Medicine,The First Affiliated Hospital of Hainan Medical University,Haikou Hainan 570102,China;Department of Traditional Chinese Medicine,Geriatric Hospital of Hainan,Haikou Hainan 571100,China)

机构地区：[1]海南省安宁医院神内老年科,海南海口570100 [2]海南医学院第一附属医院中医科,海南海口570102 [3]海南省老年病医院中医科,海南海口571100 [4]海南省安宁医院神经内科,海南海口570100

出　　处：《四川中医》2023年第9期138-142,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨四生散合止痉散加味治疗风痰瘀络型偏头痛患者疗效及对血清丙二醛(MDA)、一氧化氮(NO)水平的影响。方法:选取2021年10月-2022年12月我院收治的风痰瘀络型偏头痛患者90例为观察对象,通过随机数字表法分为中药汤剂组和常规治疗组各45例,常规治疗组给予盐酸氟桂利嗪胶囊治疗,中药汤剂组在此基础上给予四生散合止痉散加味治疗,比较两组治疗后的中医证候疗效、中医症状积分、偏头痛发作情况、颅内动脉血流情况、机体自由基平衡状况[丙二醛(MDA)、一氧化氮(NO)及超氧化物歧化酶(SOD)水平]及不良反应发生情况。结果:治疗后,中药汤剂组总有效率(93.33%)明显高于常规治疗组(77.78%),差异有统计学意义(P<0.05)。治疗后,两组头痛、眩晕、呕吐、心烦易怒、胸闷评分及总积分均显著降低(P<0.05),且中药汤剂组各分值明显低于常规治疗组(P<0.05)。治疗后,两组偏头痛发作频率、发作持续时间及疼痛程度均显著降低(P<0.05),且中药汤剂组明显低于常规治疗组(P<0.05)。治疗后,两组大脑前动脉、大脑后动脉、椎动脉及基底动脉平均血流速度均显著降低(P<0.05),且中药汤剂组明显低于常规治疗组(P<0.05)。治疗后,两组MDA、NO水平均显著降低(P<0.05),SOD水平均显著升高(P<0.05),且中药汤剂组MDA、NO水平明显低于常规治疗组(P<0.05),SOD水平明显高于常规治疗组(P<0.05)。治疗期间,两组均无明显不良反应发生。结论:四生散合止痉散加味治疗风痰瘀络型偏头痛患者疗效显著,可有效善患者临床症状、颅内动脉血流及机体自由基紊乱状况,用药安全,有较高临床应用价值。Objective:To investigate the efficacy of modified Sisheng powder with Zhijing powder in the treatment of patients with migraine of wind phlegm stasis collaterals syndrome and its influence on levels of serum malondialdehyde(MDA)and nitric oxide(NO).Methods:90patients with migraine of wind phlegm stasis collaterals syndrome who were treated in the hospital from October 2021to December 2022were selected as the observation subjects,and they were divided into TCM decoction group and conventional treatment group,with 45cases in each group by using the random number table method.The conventional treatment group was treated with flunarizine hydrochloride capsule,while the TCM decoction group was given modified Sisheng powder with Zhijing powder on this basis.The efficacy of TCM syndromes,TCM symptoms scores,migraine attack,intracranial arterial blood flow,body’s free radical balance[MDA,NO,superoxide dismutase(SOD)]and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate in TCM decoction group(93.33%)was significantly higher than that in conventional treatment group(77.78%)(P<0.05).After treatment,the scores of headache,dizziness,vomiting,irritability and chest tightness and total score in both groups were significantly decreased(P<0.05),the scores in TCM decoction group were significantly lower than those in conventional treatment group(P<0.05).After treatment,the migraine attack frequency,attack duration and pain degree were significantly reduced in both groups(P<0.05),and the above indicators were significantly lower in TCM decoction group than those in conventional treatment group(P<0.05).The average blood flow velocities of anterior cerebral artery,posterior cerebral artery,vertebral artery and basilar artery in both groups was significantly declined after treatment(P<0.05),and the indicators in TCM decoction group were significantly lower than those in conventional treatment group(P<0.05).After treatment,the levels of MDA and NO levels in the two groups were sig

关 键 词：风痰瘀络 偏头痛 四生散 止痉散 丙二醛 一氧化氮 氧自由基 

分 类 号：R747.2[医药卫生—神经病学与精神病学]