血清UA、HDL、NGF及游离甲状腺素水平与双相情感障碍患者病情严重程度的相关性分析  

Correlation analysis of serum UA,HDL,NGF and FT4 levels with the severity of patients with bipolar disorder

作　　者：喻军海 李清 万娜萍 YU Junhai;LI Qing;WAN Naping(Third Ward,Qingyunpu Hospital of Jiangxi Provincial Psychiatric Hospital,Nanchang,Jiangxi 330001,China;Department of Pharmacy,Jiangxi Provincial Psychiatric Hospital,Nanchang,Jiangxi 330001,China;Department of Psychology,Jiangxi Provincial Psychiatric Hospital,Nanchang,Jiangxi 330029,China)

机构地区：[1]江西省精神病院青云谱院区三病区,江西南昌330001 [2]江西省精神病院药剂科,江西南昌330001 [3]江西省精神病院心理科,江西南昌330001

出　　处：《检验医学与临床》2023年第21期3114-3117,共4页Laboratory Medicine and Clinic

基　　金：江西省卫生健康委员会科技计划项目(202311303)。

摘　　要：目的分析血清尿酸(UA)、高密度脂蛋白(HDL)、神经生长因子(NGF)及游离甲状腺素(FT4)水平与双相情感障碍患者病情严重程度的相关性,以期为该病的临床诊断及治疗提供参考。方法选取2021年10月至2022年10月江西省精神病院收治的65例双相情感障碍患者作为观察组,根据汉密顿抑郁量表(HAMD)评分及杨氏躁狂评定量表(YMRS)评分结果将患者分为轻度组、中度组和重度组;选取同期于该院行健康体检的健康成年人50例作为对照组。观察并比较观察组和对照组研究对象的血清UA、HDL、NGF和FT4水平及不同病情程度患者的HAMD、YMRS评分;采用Pearson相关分析血清UA、HDL、NGF及FT4水平与双相情感障碍患者HAMD、YMRS评分的相关性。结果观察组血清UA、FT4水平高于对照组,而血清NGF、HDL水平低于对照组,差异均有统计学意义(P<0.05)。重度组HAMD、YMRS评分及血清UA、FT4水平高于中度组和轻度组,且中度组高于轻度组,差异均有统计学意义(P<0.05)。重度组血清NGF、HDL水平低于中度组和轻度组,且中度组低于轻度组,差异均有统计学意义(P<0.05)。双相情感障碍患者的血清UA、FT4水平与HAMD、YMRS评分呈正相关(P<0.05),而血清NGF、HDL水平与HAMD、YMRS评分呈负相关(P<0.05)。结论随着病情严重程度的增加,双相情感障碍患者血清UA、HDL、NGF及FT4水平变化明显,故血清UA、HDL、NGF及FT4水平与双相情感障碍严重程度密切相关。Objective To analyze the correlation between serum uric acid(UA),high density lipoprotein(HDL),nerve growth factor(NGF)and free thyroxin(FT4)levels and the severity of patients with bipolar disorder,in order to provide reference for clinical diagnosis and treatment of the disease.Methods A total of 65 patients with bipolar disorder enrolled in Jiangxi Provincial Psychiatric Hospital from October 2021 to October 2022 were selected as the observation group,who were divided into mild group,moderate group and severe group based on the scores of Hamilton Depression Scale(HAMD)and Young′s Mania Rating Scale(YMRS).Meanwhile 50 healthy adults underwent physical examination in Jiangxi Provincial Psychiatric Hospital were selected as the control group.The levels of serum UA,HDL,NGF and FT4 in the observation group and the control group,as well as the scores of HAMD and YMRS of patients with different degree of bipolar disorder were observed and compared.Pearson correlation was used to analyze the correlation between serum UA,HDL,NGF and FT4 levels and HAMD and YMRS scores of patients with bipolar disorder.Results The serum UA and FT4 levels of the observation group were higher than those of the control group,while the serum NGF and HDL levels were lower than those of the control group,and the differences were all statistically significant(P<0.05).The HAMD and YMRS scores and serum UA and FT4 levels in the severe group were higher than those in the moderate group and the mild groups,while the HAMD and YMRS scores and serum UA and FT4 levels in the moderate group were higher than those in the mild group,and the differences had statistical significance(P<0.05).The serum NGF and HDL levels in the severe group were lower than those in the moderate group and the mild group,while the serum NGF and HDL levels in the moderate group were lower than those in the mild group,and the differences were statistically significant(P<0.05).Serum UA and FT4 levels of patients with bipolar disorder were positively correlated with HAMD and YMR

关 键 词：尿酸 高密度脂蛋白 神经生长因子 游离甲状腺激素 双相情感障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]