肿瘤微环境在弥漫大B细胞淋巴瘤中的研究进展  

Research progress of tumor microenvironment in diffuse large B cell lymphoma

作　　者：隋京辰 颜晓菁[1] SUI Jingchen;YAN Xiaojing(Department of Hematology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院血液内科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2023年第22期4252-4256,共5页Journal of Modern Oncology

摘　　要：肿瘤微环境在肿瘤的发生发展过程扮演重要的角色。以前我们认为弥漫大B细胞淋巴瘤是由细胞恶性增殖所致,而基因表达谱研究提示肿瘤微环境成分参与了弥漫大B细胞淋巴瘤的进展。基质细胞、淋巴瘤细胞及其分泌的细胞外基质成分相互作用促进肿瘤细胞的增殖、迁移、侵袭、耐药和免疫逃逸。近年来肿瘤微环境对弥漫大B细胞淋巴瘤患者生存的影响仍存在争议,本文对此进行总结。Tumor microenvironment(TME) plays an important role in the development of tumor.Previously,diffuse large B cell lymphoma(DLBCL) was believed to be caused by malignant cell proliferation,and gene expression profile(GEP) studies showed that tumor microenvironmental components were involved in the development of diffuse large B cell lymphoma.Stromal cells,lymphoma cells and the extracellular matrix componentssecreted by them interact with each other to promote tumor cell proliferation,migration,invasion,drug resistance and immune escape.The impact of TME in DLBCL remains controversial.The effects of TME components on diffuse large B cell lymphoma were summarized in this paper.

关 键 词：肿瘤微环境 弥漫大B细胞淋巴瘤 肿瘤相关巨噬细胞 肿瘤相关成纤维细胞 

分 类 号：R730.2[医药卫生—肿瘤]