PON3Ala99Ala基因多态性与散发性肌萎缩侧索硬化易感性关联研究  

Association study of PON3Ala99Ala gene polymorphisms and susceptibility to sporadic amyotrophic lateral sclerosis

作　　者：范志亮[1,2] 李春岩[1] 姜虹[1] 田新英[1] Fan Zhiliang;Li Chunyan;Jiang Hong;Tian Xinying(Department of Neurology,the Second Hospital of Hebei Medical University,Key Laboratory of Neurology of Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院神经内科,河北省神经病学重点实验室,石家庄050000 [2]邢台市人民医院神经内三科

出　　处：《脑与神经疾病杂志》2023年第11期661-664,共4页Journal of Brain and Nervous Diseases

基　　金：河北省医学科学研究计划课题(20201582)。

摘　　要：目的探讨散发性肌萎缩侧索硬化(sALS)发病是否与对氧磷酶3(PON3)Ala99Ala基因多态性相关.方法应用聚合酶链式反应-限制性酶切片段长度多态性(PCR-RFLP)对117例健康对照和108例sALS患者进行PON3Ala99Ala基因多态性分析.结果本研究中病例组与健康对照组人群PON3Ala99Ala基因多态性符合Hardy-Weinberg遗传平衡定律,具有代表性.sALS组与对照组之间PON3 Ala99Ala基因的三种基因型分布比较无差异(P=0.157).PON3 Ala99Ala基因A和G等位基因分布在对照组、sALS组中进行组间比较,差异无统计学意义(P=0.257).与AA基因型比较,AG基因型、GG基因型和AG+GG基因型均不增加患sALS的风险(分别为OR=1.68,95%CI=0.95~2.98;OR=0.63,95%CI=0.11~3.54;OR=1.55,95%CI=0.89~2.71).结论PON3Ala99Ala基因多态性不增加sALS发病易感性.Objective To investigate whether sporadic amyotrophic lateral sclerosis(sALS)is associated with paraoxonases(PON3)Ala99Ala gene polymorphism.Methods Polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP)was used to analyze PON3Ala99Ala gene polymorphism in 117 healthy controls and 108 patients with sALS.Results In this study,the PON3Ala99Ala gene polymorphism in the case group and the healthy control group conforms to Hardy Weinberg's genetic balance law,which is representative.There was no difference in the distribution of three genotypes of PON3 Ala99Ala gene between the sALS group and the control group(P=0.157).The distribution of A and G alleles of PON3 Ala99Ala gene in the control group and sALS group was compared between groups,and no statistical dfference was found(P=0.257).Compared with AA genotype,AG genotype,GG genotype and AG+GG genotype did not increase the risk of sALS(OR=1.68,95%CI=0.95-2.98;OR=0.63,95%CI=0.11-3.54;OR=1.55,95%CI=0.89-2.71,respectively).Conclusion PON3Ala99Ala gene polymorphism does not increase the susceptibility to sALS.

关 键 词：肌萎缩侧索硬化 对氧磷酶3 基因 多态性 

分 类 号：R746.4[医药卫生—神经病学与精神病学]