白细胞介素-10在维持肠道稳态中的作用研究进展  

Research Progress on the Role of Interleukin-10 in MaintainingIntestinal Homeostasis

作　　者：童乐 李梅[1,3] 唐小涵 黄玲[1,3] 张长城[1,3] 郭煜晖[1,3] TONG Le;LI Mei;TANG Xiaohan;HUANG Ling;ZHANG Changcheng;GUO Yuhui(Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,Medical College,China Three Gorges University,Yichang 443002,China;College of Basic Medical Science,China Three Gorges University,Yichang 443002,China;College of Medicine and Health Sciences,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室,宜昌443002 [2]三峡大学基础医学院,宜昌443002 [3]三峡大学健康医学院,宜昌443002

出　　处：《中国细胞生物学学报》2023年第9期1409-1418,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81873349)资助的课题。

摘　　要：肠道稳态是宿主肠道黏膜和免疫屏障、肠道环境、营养物质和代谢产物等相互作用而形成的动态平衡状态。白细胞介素-10(interleukin-10,IL-10)是IL-10细胞因子家族的成员之一,是免疫反应中重要的抗炎细胞因子,在维持肠道稳态中发挥重要作用。该文从IL-10在维持肠上皮细胞稳态、肠屏障完整性、肠道菌群平衡以及在肠道中的抗炎作用四个方面对IL-10在维持肠道稳态中作用的研究进展作一综述,并对IL-10在肠道疾病中的治疗前景进行展望。Intestinal homeostasis is a dynamic equilibrium state formed by the interaction of the host intestinal mucosa and immune barrier,intestinal environment,nutrients and metabolites.IL-10(interleukin-10),amember of the IL-10 cytokine family,is an important anti-inflammatory cytokine in the immune response and playsan important role in maintaining intestinal homeostasis.This article reviewed the research progress of the role ofIl-10 in maintaining intestinal homeostasis from four aspects:the maintenance of intestinal epithelial homeostasis,the integrity of intestinal barrier,the balance of gut microbiota and the anti-inflammatory effect in the intestine,thetherapeutic prospect of IL-10 in intestinal diseases was prospected.

关 键 词：白细胞介素-10 肠道稳态 肠上皮细胞 肠屏障 肠道菌群 

分 类 号：R574[医药卫生—消化系统]