施万细胞可塑性和自噬对周围神经损伤修复的作用  

Role of Schwann Cell Plasticity and Autophagy in Peripheral Nerve Injury Repair

作　　者：肖海丽 袁真 魏超 罗军[1] XIAO Hai-li;YUAN Zhen;WEI Chao;LUO Jun(Department of Rehabilitation Medicine,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院康复科,南昌330006

出　　处：《南昌大学学报（医学版）》2023年第5期87-91,共5页Journal of Nanchang University：Medical Sciences

基　　金：国家重点研发项目(2020YFC2005800)。

摘　　要：周围神经系统在神经损伤后会表现出比中枢神经系统更强的再生能力,这得益于施万细胞显著的可塑性。可塑性是指施万细胞对损伤作出的反应,即去分化、激活或重新编程,其中包括激活自噬清除髓鞘碎片,而髓鞘清除对周围神经损伤的再生至关重要。自噬是神经元发育和生存所必需的细胞降解过程,尤其是在抵抗异常应力时,通过消除受损的蛋白质和细胞器来维持细胞稳态发挥了不可替代作用。神经受损后的自噬调节作用与施万细胞可塑性密切相关,自噬广泛参与了神经损伤后施万细胞可塑性的调节,其中包括促分化,以及调节轴突发生等。The peripheral nervous system shows a greater capacity to regenerate after nerve injury than the central nervous system,which benefits from the remarkable plasticity of Schwann cells.Plasticity refers to the response of Schwann cells to injury by dedifferentiation,activation,or reprogramming.The activation of autophagy to remove myelin debris is essential for the regeneration of peripheral nerve injury.Autophagy is a cell degradation process necessary for the development and survival of neurons.It plays an irreplaceable role in maintaining cell homeostasis by eliminating damaged proteins and organelles,especially when resisting abnormal stress.The regulation of autophagy after nerve injury is closely related to the plasticity of Schwann cells.Autophagy is widely involved in the regulation of Schwann cell plasticity after nerve injury,including promoting differentiation and regulating axonogenesis.

关 键 词：施万细胞 细胞自噬 周围神经 修复损伤 

分 类 号：R745[医药卫生—神经病学与精神病学]