支气管动脉化疗栓塞介入治疗非小细胞肺癌患者的临床效果研究  

Clinical study of bronchial arterial chemoembolization interventional therapy in patients with non-small cell lung cancer

作　　者：王兆映 杨培培[1] 袁牧[1] 谢波[1] 谭玉林[1] Wang Zhaoying;Yang Peipei;Yuan Mu(The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000)

机构地区：[1]蚌埠医学院第一附属医院介入科,安徽蚌埠233000

出　　处：《中国现代医药杂志》2023年第10期37-41,共5页Modern Medicine Journal of China

基　　金：北京医学奖励基金会课题(编号:YXJL-2022-0105-0027)。

摘　　要：目的 探究支气管动脉化疗栓塞(Bronchial arterial chemoembolization,BACE)治疗非小细胞肺癌(Nonsmall cell lung cancer,NSCLC)患者的临床疗效及安全性。方法 选取我院2021年5月~2022年5月收治的经病理证实为NSCLC的患者92例,根据治疗方法分为观察组和对照组。其中观察组46例患者接受BACE治疗,对照组46例患者采用传统静脉化疗,比较两组患者的短期疗效、炎症因子指标变化、生活质量差异,评价两组患者不良反应发生情况。结果 观察组的客观有效率为76.09%、疾病控制率为95.65,均高于对照组的56.52%和82.61%,差异有统计学意义(P<0.05);观察组术后炎性因子血清粒细胞-巨噬细胞集落刺激因子(GM-CSF)、肿瘤坏死因子-α(TNF-α)、白介素(IL)-2、IL-8水平较对照组降低,差异有统计学意义(P<0.05);观察组术后生活质量评分高于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论 BACE治疗NSCLC患者安全可靠、不良反应少,既可以提高患者治疗效果,又能够改善患者的生活质量,值得在临床推广。Objective To investigate the clinical efficacy and safety of bronchial arterial chemoembolization(BACE)interventienal therapy in patients with non-small cell lung cancer(NSCLC).Methods A total of 92 patients with NSCLC admitted to our hospital from May 2021 to May 2022 were selected as the subjects,and they were divided into control group(46 cases)and observation group(46 cases).46 patients in the control group were treated with traditional perfusion chemotherapy,and 46 patients in the observation group were treated with BACE interventional therapy.The short-term efficacy,changes in inflammatory factor indexes,differences in quality of life and the incidence of adverse reactions were compared between the two groups.Results The objective effectiveness rate of the observation group was 76.09%and the disease control rate was 95.65%,both higher than 56.52%and 82.61%of the control group,the differences were statistically significant(P<0.05).The levels of postoperative inflammatory factors GM-CSF,TNF-α,IL-2 and IL-8 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The postoperative quality of life score in the observation group was higher than that of the control group,the incidence of adverse reactions in the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion BACE treatment for NSCLC patients is safe and reliable,with fewer adverse reactions.It can improve both the treatment effect and the quality of life of patients.

关 键 词：支气管动脉化疗栓塞 非小细胞肺癌 疗效分析 

分 类 号：R734.2[医药卫生—肿瘤]