肺器官芯片的构建及应用  

Construction and application of lung-on-a-chip

作　　者：刘含 孙美好 李建生[1] LIU Han;SUN Mei-hao;LI Jian-sheng(Henan University of Chinese Medicine,Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province&Education Ministry of China,Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Zhengzhou 450016,China)

机构地区：[1]河南中医药大学,呼吸疾病中医药防治省部共建协同创新中心,河南省中医药防治呼吸病重点实验室,河南郑州450016

出　　处：《中国药理学通报》2023年第11期2022-2028,共7页Chinese Pharmacological Bulletin

基　　金：国家“万人计划”-百千万工程领军人才项目(组厅字[2016]37号);国家自然科学基金资助项目(No 11902245);中国博士后科学基金资助项目(No 2021M690938);河南省重点研发与推广专项(科技攻关)(No 222102310183)。

摘　　要：肺器官芯片是一种基于微流控芯片的3D细胞培养系统,能更准确的模拟人体细胞R微环境,在生物医学工程等领域具有广阔的应用前景。该文主要综述了肺器官芯片的制备技术,常见肺器官芯片的构建及相关疾病机制的研究,肺器官芯片在毒性检测、药效药理评价和精准医疗领域的应用等,进一步分析了现有肺器官芯片的不足,同时结合多学科交叉等领域对其发展方向进行了思考,以期为肺部疾病的基础研究及临床防治提供参考。Lung-on-a-chip is a microfluidic chip-based 3D cell culture system,which can more accurately simulate the in vivo cell microenvironment and is widely used in biomedical engineering and other fields.This paper mainly reviews the preparation and application of lung-on-a-chip,and looks into its future development direction by combining multidisciplinary intersection,in order to provide reference for the prevention and treatment research of lung diseases.

关 键 词：肺器官芯片 3D打印 呼吸系统疾病 病理模型 药效药理评价 精准医疗 

分 类 号：R-05[医药卫生] R-332R332.2R318R363-332R56