新一代测序技术在肺癌精准诊疗中的应用进展  

Application Progress of Next-generation Sequencing Technology in Precision Medicine for Lung Cancer

作　　者：周涛[1] 王雅梅[2] ZHOU Tao;WANG Yamei(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学,北京100069 [2]首都医科大学基础医学院生化与分子生物学系,北京100069

出　　处：《医学综述》2022年第21期4199-4204,共6页Medical Recapitulate

基　　金：北京市教育委员会科技计划一般项目(SQKM2017-10025005);首都医科大学长学制导师立项项目(7NZDS2020014);首都医科大学本科生科研创新项目(XSKY2021025)。

摘　　要：新一代测序(NGS)技术具有高测序深度、低检测成本、大规模多基因并行测序的优势,被广泛应用于生命科学、医学各领域。肺癌是全球范围内发病率和病死率最高的恶性肿瘤,病因复杂,早期症状轻且不易检出、晚期预后差、高转移率和耐药性等特征严重影响患者的生命健康。随着NGS技术的深入应用,肺癌的精准分型、精准治疗策略制订、耐药机制分析以及疗效评估等方面的研究取得了很大突破。未来,NGS技术将进一步推动肺癌个体化精准医疗的进展。Next-generation sequencing(NGS)technology is widely used in research in life sciences and medicine due to its advantages of high sequencing depth,low cost,and large-scale multi-gene parallel sequencing.Lung cancer is the malignant tumor with the highest morbidity and mortality in the world.Due to its complex etiology,difficulty in detection at an early stage,poor prognosis in the late stage,high metastasis rate,and drug resistance,it seriously impacts the life and health of the patients.The in-depth application of NGS technology has made great breakthroughs in the research of precise typing,treatment strategy formulation,drug resistance mechanism analysis and efficacy evaluation of lung cancer.In the future,NGS technology will further promote the process of individualized and precise treatment of lung cancer.

关 键 词：肺癌 新一代测序 精准诊疗 

分 类 号：R734.2[医药卫生—肿瘤]