RNA m^(5)C甲基化在肿瘤中的研究进展  

Progress in Research of RNA m^(5)C Methylation in Tumors

作　　者：陈鹏 王黎[1] 凌生涛[1] 姚启盛[1] CHEN Peng;WANG Li;LING Shengtao;YAO Qisheng(Department of Urology,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]湖北医药学院附属太和医院泌尿外科,湖北十堰442000

出　　处：《医学综述》2022年第21期4211-4215,共5页Medical Recapitulate

基　　金：湖北省卫生健康委科研项目(WJ2019M060);十堰市引导性科研项目(21Y29)。

摘　　要：5-甲基胞嘧啶(m^(5)C)是存在于大量RNA中的表观遗传修饰物,主要存在于转运RNA中,亦存在于核糖体RNA、信使RNA、增强子RNA和一些长链非编码RNA中。RNA甲基化可以在功能上调节基因表达和细胞活动。RNA m^(5)C甲基化在非编码区附近富集,受其相关酶的动态调节,包括甲基转移酶、去甲基化酶以及结合蛋白。m^(5)C参与了多种RNA代谢,包括信使RNA输出、RNA稳定性和翻译。机体m^(5)C修饰水平改变可导致线粒体功能障碍、应激反应障碍、配子发育和胚胎发育受阻、神经和脑发育异常,并参与调控肿瘤的发生发展,且m^(5)C相关修饰酶的表达与肿瘤预后密切相关。5-methylcytosine(m^(5)C)is an epigenetic modifier existing in a large number of RNAs,mainly in transport RNA,but also in ribosomal RNA,messenger RNA,enhancer RNA and some long-chain non-coding RNA.RNA methylation can functionally regulate gene expression and cell activity.RNA m^(5)C methylation is enriched near the non-coding region and is dynamically regulated by its related enzymes,including methyltransferases,demethylases and binding proteins.m^(5)C is involved in a variety of RNA metabolism,including messenger RNA output,RNA stability and translation.Changes in the level of m^(5)C modification in the body can lead to mitochondrial dysfunction,stress response disorder,gamete development and embryo development restriction,neural and brain development abnormalities,regulate the occurrence and development of tumor,and the expression of m^(5)C-related modifying enzymes is closely related to the prognosis of tumor.

关 键 词：肿瘤 RNA甲基化 5-甲基胞嘧啶甲基化 

分 类 号：R730.2[医药卫生—肿瘤]