线粒体嵴重塑蛋白Mic60/Mitofilin在程序性坏死相关缺血再灌注损伤中的潜在作用  

Potential Role of Mitochondrial Cristae Remodeling Protein Mic60/Mitofilin in Necroptosis Related Ischemia-reperfusion Injury

作　　者：侯慧芳[1] 石文千 赵婷婷 孙文浩 何善元 梅大泺 赵聆卉 安晓鸽 李东亮 HOU Huifang;SHI Wenqian;ZHAO Tingting;SUN Wenhao;HE Shanyuan;MEI Daluo;ZHAO Linghui;AN Xiaoge;LI Dongliang(School of Basic Medicine Sciences,Xinxiang Medical University,Xinxiang 453003,China;the First Clinical College,Xinxiang Medical University,Xinxiang 453003,China;Sanquan College of Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453003 [2]新乡医学院第一临床学院,河南新乡453003 [3]新乡医学院三全学院,河南新乡453003

出　　处：《医学综述》2022年第22期4387-4393,共7页Medical Recapitulate

基　　金：河南省教育厅大学生创新创业训练计划项目(S201910472026);河南省高等学校重点科研项目(19A310022,20A310015)。

摘　　要：缺血再灌注损伤(IRI)是临床治疗缺血性疾病亟须攻克的难题。近年来,程序性坏死被认为是IRI导致细胞死亡的重要形式,其通过膜受体和细胞内信号转导分子的调控在IRI中发挥重要作用。而线粒体嵴重塑与IRI联系密切,其调控与线粒体融合分裂、氧化应激等有关。Mic60/Mitofilin作为一种线粒体内膜蛋白,可通过嵴重塑调控线粒体结构和功能,进而影响细胞命运转归,其可能通过影响细胞死亡在程序性坏死相关IRI中发挥作用。未来,阐明程序性坏死相关IRI中维持线粒体蛋白稳态的作用及机制可为缺血性疾病的治疗提供新思路。Ischemia-reperfusion injury(IRI)is an urgent problem in clinical treatment of ischemic diseases.In recent years,necroptosis has been considered as an important form of IRI leading to cell death.It plays an important role in IRI through the regulation of membrane receptors and intracellular signal transduction molecules.Mitochondrial cristae remodeling is closely related to IRI,and its regulation is related to mitochondrial fusion and fission,oxidative stress,etc.As a mitochondrial inner membrane protein,Mic60/Mitofilin can regulate mitochondrial structure and function through cristae remodeling,and then affect the cell fate.Mic60/Mitofilin may play a role in necroptosis related IRI by affecting cell death.In the future,elucidating the role and mechanism of maintaining mitochondrial protein homeostasis in necroptosis associated IRI may provide new ideas for the treatment of ischemic diseases.

关 键 词：缺血再灌注损伤 程序性坏死 Mic60/Mitofilin 嵴重塑 

分 类 号：R743.3[医药卫生—神经病学与精神病学]