非酒精性脂肪性肝病患者丙氨酸转氨酶升高的临床价值  

Clinical Value of Elevated Alanine Transaminase Level in Patients with Non-alcoholic Fatty Liver Disease

作　　者：郑佳睿 封波[1,2] ZHENG Jiarui;FENG Bo(Department of Hepatology,Peking University People′s Hospital,Beijing 100044,China;Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases,Peking University Hepatology Institute,Beijing 100044,China)

机构地区：[1]北京大学人民医院肝病科,北京100044 [2]北京大学肝病研究所北京市丙型肝炎和肝病免疫重点实验室,北京100044

出　　处：《医学综述》2023年第1期91-97,共7页Medical Recapitulate

基　　金：北京市临床重点专科项目(京卫医〔2020〕129号)。

摘　　要：近年来非酒精性脂肪性肝病(NAFLD)已成为全球性慢性肝病最常见的原因,其中非酒精性脂肪性肝炎(NASH)与NAFLD相关终末期肝病的发生密切相关,如何在NAFLD中识别出NASH并积极干预成为控制NAFLD进展的关键。丙氨酸转氨酶(ALT)在临床上常被认为是评估肝病活动和肝损伤严重程度的指标,也被证明是诊断NAFLD的独立预测因子,但其在NAFLD中的临床价值尚存在争议,由于肝脏穿刺的有创性,临床医师往往基于ALT水平作为保肝治疗的依据。深入研究NAFLD患者中ALT升高的临床价值,可为NAFLD的早期发现、早期有效管理与监测提供参考。In recent years,non-alcoholic fatty liver disease(NAFLD)has become the most common cause of chronic liver diseases in the world.Among them,non-alcoholic steatohepatitis(NASH)is closely related to the occurrence of NAFLD related end-stage liver diseases.How to identify NASH in NAFLD and actively intervene has become the key to control the progress of NAFLD.Alanine transferase(ALT)is often considered as an index to evaluate the activity of liver disease and the severity of liver injury in clinical practice,which has also been proved to be an independent predictor of NAFLD,however,its clinical value in NAFLD is still controversial.Due to the invasive nature of liver perforation,clinicians usually use the level of ALT as the basis of liver protection treatment.In-depth study of the clinical significance of elevated ALT in patients with NAFLD,can provide reference for the early detection,early effective management and monitoring of NAFLD.

关 键 词：非酒精性脂肪性肝病 非酒精性脂肪性肝炎 丙氨酸转氨酶 进展期肝纤维化 肝细胞癌 

分 类 号：R575.5[医药卫生—消化系统]