神经调节蛋白-1对神经肌肉系统影响的研究进展  

Research Progress in Effect of Neuregulin-1 on Neuromuscular System

作　　者：彭文蕊 蒋鹏[1] 吴进 PENG Wenrui;JIANG Peng;WU Jin(Department of Anesthesiology,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China;School of Medicine,Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院麻醉科,江苏镇江212001 [2]江苏大学医学院,江苏镇江212001

出　　处：《医学综述》2023年第3期452-457,共6页Medical Recapitulate

基　　金：江苏省高层次创新创业人才引进计划--双创博士(SCBS201801);江苏大学附属医院博士启动基金(jdfyRC2017008)。

摘　　要：神经调节蛋白(NRG)家族对神经肌肉系统的发育和维持有重要作用,其中NRG-1被研究得最多,且与神经肌肉系统的关系也最为密切。NRG-1通过与细胞表面Ⅰ型酪氨酸激酶受体结合,促进神经肌肉系统的生长发育,并对各种病理条件下神经肌肉系统的损伤产生保护作用。磷脂酰肌醇-3-激酶/蛋白激酶B、过氧化物酶体增殖物激活受体/核因子κB等信号通路是NRG-1在细胞内发挥作用的主要信号通路。今后还需进一步开展临床转化研究,明确NRG-1是否可以应用于神经肌肉系统疾病患者。The neuregulin(NRG)family plays an important role in the development and maintenance of the neuromuscular system.Among them,NRG-1 is the most studied,which has the closest relationship with the neuromuscular system.NRG-1 promotes the growth and development of the neuromuscular system by binding with typeⅠtyrosine kinase receptors on the cell surface,and has a protective effect on the injury of the neuromuscular system under various pathological conditions.Signaling pathways such as phosphatidylinositol-3-kinase/protein kinase B,peroxisome proliferator-activated receptor/nuclear factor-κB are the main signal pathways for NRG-1 to play a role in cells.In the future,further clinical translational research is needed to determine whether NRG-1 can be applied to patients with neuromuscular diseases.

关 键 词：神经调节蛋白-1 神经肌肉系统 酪氨酸激酶受体 磷脂酰肌醇-3-激酶/蛋白激酶B 

分 类 号：R746[医药卫生—神经病学与精神病学]