Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells  

作　　者：Mathieu Adjemout Bruno Pouvelle Fatou Thiam Alassane Thiam Magali Torres Samia Nisar Babacar Mbengue Alioune Dieye Pascal Rihet Sandrine Marquet 

机构地区：[1]Institut National de la SantéEt de la Recherche Médicale(INSERM),UnitéMixte de Recherche(UMR)U1090,Aix Marseille Université,TAGC Theories and Approaches of Genomic Complexity,Institut MarMaRa,Marseille,France [2]Groupe de Recherche Biotechnologie Appliquée et Bioprocédés Environnementaux(GRBA-BE),Ecole Supérieure Polytechnique,UniversitéCheikh Anta Diop de Dakar,Dakar BP5005,Senegal [3]Pole D’Immunophysiopathologie&Maladies Infectieuses(IMI),Institut Pasteur de Dakar,Dakar BP 220,Senegal [4]Service D’Immunologie,UniversitéCheikh Anta Diop de Dakar,Dakar BP5005,Senegal [5]Aix Marseille University,CNRS,Marseille 13009,France

出　　处：《Genes & Diseases》2023年第6期2210-2214,共5页基因与疾病（英文）

基　　金：supported by the African Higher Education Centers of Excellence Project(CEA-SAMEF)at UCAD,the Pasteur Institute in Dakar,the Pasteur Institute in Paris,the French Embassy in Senegal,INSERM,and Aix-Marseille University.MA and SN were supported by a Ph.D.fellowship from the French Ministry of Research and the Higher Education Commission(HEC)in Pakistan,respectively;support from the French Government under the France 2030 Investment Plan,as part of the Initiative d'Excellence d'Aix-Marseille Université-A∗MIDEX-Institute MarMaRa(No.AMX-19-IET-007).

摘　　要：Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African children.The malaria parasite is transmitted by mosquitos belonging to the genus Anopheles.After an asymptomatic liver stage,the parasite is released into the bloodstream to invade red blood cells(RBCs)and replicate asexually.This erythrocytic phase is associated with a variety of clinical manifestations,including mild and severe malaria.Cerebral malaria(CM)is one of the most severe forms,characterized by the sequestration of parasitized RBCs in the small capillaries of the brain and the local development of cytokine-mediated inflammation.Genetic variants in genes encoding proteins involved in red blood cell physiology are protective factors against severe malaria,as clearly demonstrated for the sickle cell variant of hemoglobin(HbS).

关 键 词：MALARIA FALCIPARUM PLASMODIUM 

分 类 号：R53[医药卫生—内科学]