Structure,function,and pathology of Neurexin-3  

作　　者：Rui Zhang HanXiao Jiang YuanJie Liu GuiQiong He 

机构地区：[1]Chongqing Key Laboratory of Neurobiology,Chongqing Medical University,Chongqing 400016,China [2]Department of Neurology,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China [3]Department of Anatomy,Chongqing Medical University,Chongqing 400016,China

出　　处：《Genes & Diseases》2023年第5期1908-1919,共12页基因与疾病（英文）

基　　金：supported by the Science and Technology Innovation Project of Chongqing Education Commission(China)(No.KJCXZD2020021).

摘　　要：Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic membrane.Neurexin-3 has important roles in synapse development and synapse functions.Neurexin-3 mediates excitatory presynaptic differentiation by interacting with leucine-rich-repeat transmembrane neuronal proteins.Meanwhile,neurexin-3 modulates the expression of presynapticα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors andγ-aminobutyric acid A receptors by interacting with neuroligins at excitatory and inhibitory synapses.Numerous studies have documented the potential contribution of neurexin-3 to neurodegenerative and neuropsychiatric disorders,such as Alzheimer's disease,addiction behaviors,and other diseases,which raises hopes that understanding the mechanisms of neurexin-3 may hold the key to developing new strategies for related illnesses.This review comprehensively covers the literature to provide current knowledge of the structure,function,and clinical role of neurexin-3.

关 键 词：Excitatory synapses Inhibitory synapses Neural cell adhesion molecules Neurexin-3 Neurodegenerative diseases Neuropsychiatric diseases 

分 类 号：R74[医药卫生—神经病学与精神病学]