小胶质细胞介导的炎症反应在快速眼动睡眠剥夺相关认知障碍中的作用  

Role of Microglia-mediated Inflammatory Responses in Cognitive Impairment Associated with Rapid Eye Movement Sleep Deprivation

作　　者：刘亦阳 杨国帅[1] LIU Yiyang;YANG Guoshuai(Department of Neurology,Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou 570100,China)

机构地区：[1]中南大学湘雅医学院附属海口医院神经内科,海口570100

出　　处：《医学综述》2023年第6期1063-1069,共7页Medical Recapitulate

基　　金：国家自然科学基金(81860214);海南省重点研发项目(ZDYF2022SHFZ043);海南省卫生计生行业科研项目(琼卫科教〔2018〕10号)。

摘　　要：睡眠与认知密切相关,睡眠的不同周期对认知功能的影响不同,其中快速眼动(REM)睡眠可改善记忆功能,REM睡眠剥夺后会激发不同生化反应的发生,最终引起认知障碍。REM睡眠剥夺可诱导小胶质细胞活化并影响突触可塑性。活化的小胶质细胞通过介导炎症反应释放炎症因子,改变微环境,影响神经组织之间的信号传递及其功能。上述炎症因子可从影响突触功能可塑性和结构完整性等方面损害突触可塑性。近年来,小胶质细胞作为神经元和突触功能调节关键因子发挥作用的机制受到普遍关注,REM睡眠影响认知的具体机制成为研究热点。Sleep is closely related to cognition,and different periods of sleep have different effects on cognitive function,among which,rapid eye movement(REM)sleep can improve memory function.REM sleep deprivation will stimulate different biochemical reactions and eventually cause cognitive impairment.REM sleep deprivation can induce microglia activation and affect synaptic plasticity.Activated microglia releases inflammatory factors through mediating inflammatory reaction,changes the microenvironment,and affects signal transmission and function between nerve tissues.These inflammatory factors can impair synaptic plasticity by affecting synaptic functional plasticity and structure integrity.In recent years,the mechanism of microglia as a key factor in the regulation of neuronal and synaptic functions has received widespread attention,and the specific mechanism of how REM sleep affects cognition has become a research hotspot.

关 键 词：快速眼动睡眠剥夺 认知障碍 小胶质细胞 突触可塑性 炎症反应 

分 类 号：R741[医药卫生—神经病学与精神病学]