焦虑动物模型制备研究进展  

Research Progress in the Preparation of Anxiety Animal Model

作　　者：宫子涵 王艳[2] 吴珊红 马铭 王媛 代一宁 李诗雨 张紫微 韩轶 GONG Zihan;WANG Yan;WU Shanhong;MA Ming;WANG Yuan;DAI Yining;LI Shiyu;ZHANG Ziwei;HAN Yi(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Rehabilitation Centre,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第二医院康复中心,哈尔滨150001

出　　处：《医学综述》2023年第6期1170-1175,共6页Medical Recapitulate

基　　金：黑龙江省中医药管理局国医大师学术思想传承科研课题(GY2022-10)。

摘　　要：焦虑是指个体在面对潜在风险时产生的紧张、不安、忧虑等复杂情绪体验。暂时性焦虑是人体正常情绪储备,有利于促进大脑快速觉醒,及时规避潜在风险,但长期慢性焦虑或无法排解的情绪障碍则会导致精神紧张、睡眠障碍、注意力缺失甚至诱发心脑血管疾病。多种造模方式用于焦虑分子机制的探索和研究,但目前尚未找到能够完全模拟焦虑的动物模型,在一定程度上阻碍了焦虑相关研究的进展。然而,通过特定建模方式和行为学测试,可以针对焦虑的病理表现进行研究,可提供更可行的建模参考,并为焦虑动物模型提供更多选择方案。Anxiety is a complex emotional experience such as tension,uneasiness,and apprehension when an individual is faced with potential risks.Temporary anxiety is a normal emotional reserve of the human body,which helps to promote rapid brain awakening and timely avoidance of potential risks,but long-term chronic anxiety or unresolved emotional disorders can lead to mental tension,sleep disturbance,attention deficit and even induce cardiovascular and cerebrovascular diseases.Various modeling approaches have been used to explore and study the molecular mechanisms of anxiety,but animal models that can fully simulate anxiety have not yet been found,which has to some extent hindered the progress of anxiety-related research.However,specific modeling approaches and behavioral tests that can target the pathological manifestations of anxiety can provide a more feasible modeling reference and offer more options for anxiety animal models.

关 键 词：焦虑 动物模型 生理 心理 社会 

分 类 号：R749.72[医药卫生—神经病学与精神病学]