经乳晕切口乳腺纤维瘤切除术治疗乳腺纤维瘤患者的临床疗效分析  

Clinical Efficacy Analysis of Transareolar Incision Mastectomy in the Treatment of Patients with Breast Fibroids

作　　者：卢邦 朱林峰 Lu Bang;Zhu Linfeng(General Surgery Department,Fangcheng County Maternal and Child Health Hospital,Nanyang,Henan,473200,China)

机构地区：[1]方城县妇幼保健院普外科,河南南阳473200

出　　处：《黑龙江医学》2023年第21期2605-2607,共3页Heilongjiang Medical Journal

基　　金：河南省医学科技攻关项目(201800761)。

摘　　要：目的:分析在乳腺纤维瘤治疗中经乳晕切口乳腺纤维瘤切除术的临床治疗效果以及对血管内皮生长因子(VEGF)、基质金属蛋白酶9(MMP-9)水平的影响。方法:选取2021年1月—2022年2月方城县妇幼保健院收治的134例乳腺纤维瘤患者作为研究对象。随机将患者分为N组与M组,每组各67例。N组采用传统乳腺纤维瘤切除术治疗;M组采用经乳晕切口乳腺纤维瘤切除术。比较两种手术方式的临床治疗效果,包括:手术各项指标、两组患者的VEGF和MMP-9水平、治疗有效率、术后并发症、乳房美观度等。结果:治疗后,M组患者治疗有效率明显高于N组,差异有统计学意义(χ^(2)=8.022,P<0.05);治疗后,两组患者VEGF和MMP-9水平下降,且M组两项指标水平均低于N组,差异有统计学意义(t=3.208、9.048,P<0.05);M组手术时间、切口恢复时间以及住院时间均低于N组,出血量少于N组,差异有统计学意义(t=72.988、69.901、5.279、9.915,P<0.05);治疗后,M组乳晕正常、乳房对称、瘢痕接受程度等乳房美观程度高于N组,差异有统计学意义(χ^(2)=9.046、4.968、4.215,P<0.05);治疗后,M组并发症率更低,差异有统计学意义(χ^(2)=4.174,P<0.05)。结论:经乳晕切口乳腺纤维瘤切除术治疗乳腺纤维瘤术后不良反应率低,降低诱病因子水平,具有良好的治疗成效。Objective:To analyze the clinical outcomes of transareolar incision mastectomy in the treatment of breast fibroids and the effects on VEGF and MMP-9 levels.Methods:The clinical data of 134 patients with breast fibroids admitted to the hospital from January 2021 to February 2022 were selected,and the patients were randomly divided into group N and group M,with 67 cases in each group.Group N was treated with conventional mastectomy and group M was treated with transareolar incision mastectomy.The clinical treatment effects of the two surgical methods were compared,including the surgical indexes,VEGF and MMP-9 levels,treatment efficiency,postoperative complications,and breast aesthetics in both groups.Results:After treatment,the treatment efficiency of patients in group M was significantly higher than that in group N,and the difference was statistically significant(χ^(2)=8.022,P<0.05).After treatment,the levels of VEGF and MMP-9 decreased in both groups and both index levels were lower in the M group than in the N group,with statistically significant differences(t=3.208,9.048,P<0.05).Operative time,incision recovery time,and hospital stay were lower in the M group than in the N group,and bleeding was less,with statistically significant differences(t=72.988,69.901,5.279,9.915,P<0.05).After treatment,breast aesthetics such as normal areola,breast symmetry,and scar acceptance were higher in group M than in group N,and the differences were statistically significant(χ^(2)=9.046,4.968,4.215,P<0.05).After treatment,the complication rate was lower in the M group,and the difference was statistically significant(χ^(2)=4.174,P<0.05).Conclusion:Transareolar incision mastectomy for mammary fibroids is worthy of application because of its low rate of postoperative adverse effects and reduced level of causative agents.

关 键 词：乳腺纤维瘤 经乳晕切口乳腺纤维瘤切除术 血管内皮生长因子 基质金属蛋白酶9 

分 类 号：R737.9[医药卫生—肿瘤]