IL-10基因多态性与结直肠癌根治术后肺部感染程度的关联  

Association of IL-10 gene polymorphism with severity of pulmonary infection after radical surgery for colorectal cancer

作　　者：景丽萍 王棣 殷艳 黄梦丹 杨娜 JING Li-ping;WANG Di;YIN Yan;HUANG Meng-dan;YANG Na(The Eighth Hospital of Wuhan,Wuhan,Hubei 4300l0,China)

机构地区：[1]武汉市第八医院手术室,湖北武汉430010

出　　处：《中华医院感染学杂志》2023年第19期2949-2952,共4页Chinese Journal of Nosocomiology

基　　金：湖北省科研基金资助项目(2019L02111)。

摘　　要：目的 分析白细胞介素-10(IL-10)基因多态性与结直肠癌根治术后肺部感染程度的关联。方法 回顾性分析2017年1月-2020年12月武汉市第八医院收治的结直肠癌根治术后并发肺部感染患者163例的临床资料,并纳入感染组,并纳入经性别、年龄1∶1匹配的结直肠癌根治术后无肺部感染患者作为非感染组(163例),比较两组基线资料及IL-10基因rs1800871、rs1800872、rs1800896位点基因型及基因频率,采用条件Logistic回归分析评估结直肠癌根治术后并发肺部感染的危险因素,并分析IL-10基因多态性与感染程度[肺炎程度指数(PSI)]的相关性。结果 Hardy-Weinberg平衡检验显示各基因频率符合遗传平衡法则,群体代表性良好;感染组IL-10基因rs1800896位点AG/GG基因型频率及G等位基因频率高于非感染组(P<0.05);感染组IL-10基因rs1800896位点AA型患者PSI评分低于AG/GG型(P<0.05);感染组IL-10基因rs1800896位点AG/GG型与PSI评分呈正相关(r=0.814,P<0.001);条件Logistic回归分析显示,吸烟史(OR=2.450)、肺部慢性疾病史(OR=3.564)及IL-10基因rs1800896位点AG/GG型(OR=6.398)是结直肠癌根治术后并发肺部感染的危险因素(P<0.05)。结论 IL-10基因rs1800896位点AG/GG基因型及吸烟史、肺部慢性疾病史可能引起结直肠癌根治术后肺部感染风险升高,IL-10 rs1800896有望成为本地区结直肠癌术后肺部感染风险管理的基因筛查位点。OBJECTIVE To analyze the association of interleukin-10(IL-10)gene polymorphism with severity of pulmonary infection after radical surgery for colorectal cancer.METHODS The clinical data of 163 patients with pulmonary infection after radical resection of colorectal cancer between Jan.2017 and Dec.2020 in the Eighth Hospital of Wuhan were retrospectively analyzed and the patients were included in infected group,and the patients without pulmonary infection after radical resection of colorectal cancer matched by gender and age at 1:1 were enrolled as non-infected group(n=163).The baseline data and genotypes and gene frequencies at rs1800871,rsl800872 and rs1800896 loci of IL-10 gene were compared between the two groups.The risk factors for concomitant pulmonary infection after radical resection of colorectal cancer were evaluated by conditional Logistic regression analysis,and the correlation between IL-10 gene polymorphism and infection severity Epneumonia severity index(PSID)J was analyzed.RESULTS Hardy-Weinberg equilibrium test showed that the frequencies of each gene were in accordance with the law of genetic equilibrium, and the population was well represented. The AG/GG genotypefrequency and G allele frequency at rs1800896 locus of IL-10 gene in infected group were higher than those innon-infected group (P<0.05). The PSI score of patients with AA genotype at rs1800896 locus of IL-10 gene in infectedgroup was lower than that of patients with AG/GG genotype (P<0.05). Spearman rank correlation analysisshowed that the AG/GG genotype at rs1800896 locus of IL-10 gene was positively correlated with PSI score ininfected group (r= 0.814, P<0.001). Conditional Logistic regression analysis showed that smoking history (OR =2.450), history of chronic lung disease (OR=3.564) and AG/GG genotype at rs1800896 locus of IL-10 gene(OR=6.398) were risk factors for concomitant pulmonary infection after radical resection of colorectal cancer(P<0.05). CONCLUSION AG/GG genotype at rs1800896 locus of IL-10 gene, smoking history and hist

关 键 词：结直肠癌 根治术 肺部感染 危险因素 白细胞介素-10 基因多态性 

分 类 号：R735.37[医药卫生—肿瘤]