生物钟节律与阿尔茨海默病治疗的研究进展  

Research Progress in Circadian Rhythm and the Treatment of Alzheimer′s Disease

作　　者：梅瑛娜 高凌[1] MEI Yingna;GAO Ling(Department of Endocrinology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院内分泌科,武汉430060

出　　处：《医学综述》2023年第13期2579-2584,共6页Medical Recapitulate

基　　金：国家自然科学基金(81571376)。

摘　　要：阿尔茨海默病(AD)是一种进展性、破坏性的神经退行性疾病。生物钟节律受视交叉上核调节构成了约24 h的自然周期,在调节人体睡眠、摄食等生理过程中起重要作用。很多AD患者存在生物钟节律紊乱,其生物钟节律紊乱可能进一步加剧疾病进展,形成有害的双向联系。因此,干预生物钟节律,包括光照疗法、褪黑素补充疗法、间歇性禁食疗法和自噬干预疗法等,可能对延缓AD进展具有重要临床意义。深入研究生物钟节律对AD的调节作用可能成为预防和缓解AD进展的新方向。Alzheimer′s disease(AD)is a progressive and destructive neurodegenerative disease.Circadian rhythm is regulated by suprachiasmatic nucleus,which constitutes a natural cycle of about 24 h and plays an important role in regulating the physiological processes of human body such as sleep and ingestion.The circadian rhythm is disturbed in many AD patients,which may further aggravate the progression of the disease and form a harmful bidirectional association.Therefore,interventions of circadian rhythm,including light therapy,melatonin supplement therapy,intermittent fasting therapy and autophagy intervention,may have great clinical significance in delaying the progression of AD.Further study on the regulating effect of circadian rhythm on AD may be a new direction for the prevention and mitigation of AD.

关 键 词：阿尔茨海默病 生物钟节律 节律干预 

分 类 号：R749.16[医药卫生—神经病学与精神病学]