核心蛋白聚糖的生物学功能概述  

An Overview of Biological Functions of Decorin

作　　者：赵慧强 韩巧君 易静 杜海涛 王华 欧敏 ZHAO Huiqiang;HAN Qiaojun;YI Jing;DU Haitao;WANG Hua;OU Min(Department Six of Healthcare,the Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100048,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]解放军总医院第二医学中心保健六科,国家老年疾病临床医学研究中心,北京100048 [2]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《医学综述》2023年第20期4044-4050,共7页Medical Recapitulate

基　　金：中国人民解放军总医院第六医学中心创新培育基金资助项目(CXPY201904)。

摘　　要：核心蛋白聚糖(Decorin)是富含亮氨酸的小分子蛋白聚糖家族成员之一,主要存在于基质和上皮细胞中,在细胞外基质的组装中发挥重要作用,它可以广泛与各种分子结合并发挥生物学作用。目前,Decorin的生物学功能研究主要集中在抗纤维化、调节血管生成、抗肿瘤3个方面。近年来,Decorin的研究进展迅速,其作用机制得到全面阐述。在Decorin的众多作用机制中,抗肿瘤作用尤为重要,其中转化生长因子-β(TGF-β)信号通路在肿瘤的发生、发展中起重要作用,Decorin可以抑制TGF-β信号通路,从而为肿瘤生物治疗提供新的思路和方向,有着良好的临床应用前景。Decorin is a member of the leucine-rich small proteoglycan family,which mainly exists in stromal and epithelial cells.It plays an important role in the assembly of extracellular matrix,which can combine with a wide range of molecules and play a biological role.At present,studies on the biological functions of decorin mainly focus on anti-fibrosis,angiogenesis regulation,and anti-tumor.In recent years,the research of decorin has made rapid progress,and its mechanism has been fully elaborated.Among the numerous mechanisms of action of decorin,its anti-tumor effect is particularly important,among which transforming growth factor-β(TGF-β)signaling pathway plays an important role in the occurrence and deve-lopment of tumors.Decorin can inhibit TGF-βsignaling pathway,thus providing a new idea and direction for tumor biological therapy,which has a good clinical application prospect.

关 键 词：核心蛋白聚糖 生物学功能 抗纤维化 血管生成调节 抗肿瘤 

分 类 号：R363.21[医药卫生—病理学]