胃癌腹膜转移机制的研究进展  

Research Progress in Mechanism of Peritoneal Metastasis of Gastric Cancer

作　　者：王统华[1] 胡静[1] 周喜汉[1] WANG Tonghua;HU Jing;ZHOU Xihan(Department of Gastroenterology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院消化内科,广西百色533000

出　　处：《医学综述》2023年第12期2345-2349,共5页Medical Recapitulate

基　　金：广西医药卫生自筹经费计划课题(Z20170235)。

摘　　要：胃癌是上消化道常见的恶性肿瘤,较多胃癌患者确诊时已经发生转移。腹膜转移是进展期胃癌最具特征性的一种转移方式。目前胃癌腹膜转移的机制尚未完全明确,且现有治疗手段的效果欠佳。Paget的“种子和土壤”学说是腹膜转移的基本理论,胃癌细胞转移是多因素共同作用的结果。手术切除、围手术期化疗或放化疗可使晚期非转移性胃癌患者获得较好预后,但转移性胃癌患者生存期无明显改善。目前胃癌腹膜转移的分子机制尚不明确,未来需进一步研究其可能的分子机制及治疗策略。Gastric cancer is a common malignant tumor in the upper gastrointestinal tract,and many patients with gastric cancer have already experienced metastasis when diagnosed.Peritoneal metastasis is the most characteristic mode of metastasis in advanced gastric cancer.At present,the mechanism of peritoneal metastasis of gastric cancer is not completely clear,and the therapeutic effect of existing treatment methods is not satisfactory.Paget′s"seed and soil"theory is the basic theory of peritoneal metastasis,and the metastasis of gastric cancer cells is the result of multiple factors.Surgical resection,perioperative chemotherapy,or radiochemotherapy can improve the prognosis of patients with advanced non-metastatic gastric cancer,but there is no significant improvement in the survival period of patients with metastatic gastric cancer.At present,the molecular mechanism of peritoneal metastasis of gastric cancer is still unclear,and further research is needed on its possible molecular mechanism and treatment strategies in the future.

关 键 词：胃癌 腹膜转移 分子机制 外泌体 

分 类 号：R735.2[医药卫生—肿瘤]