miRNA调控转化生长因子-β信号通路介导常见肝脏疾病的研究进展  

Research Progress of MicroRNA Regulating Transforming Growth Factor-βSignaling Pathway Mediating Common Liver Diseases

作　　者：吴瑞胜 黄桂东 庞智 陈勇[1] 叶晓雪[3] 周至品 WU Ruisheng;HUANG Guidong;PANG Zhi;CHEN Yong;YE Xiaoxue;ZHOU Zhipin(Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Jinxiu Shengtang Pharmaceutical Co.,Ltd.,Laibin 545700,China;Department of Pharmacy,Liuzhou People′s Hospital Affiliated to Guangxi Medical University,Liuzhou 545006,China)

机构地区：[1]广西中医药大学,南宁530200 [2]广西金秀圣堂药业有限责任公司,广西来宾545700 [3]广西医科大学附属柳州市人民医院药学部,广西柳州545006

出　　处：《医学综述》2023年第15期2920-2925,共6页Medical Recapitulate

基　　金：国家自然科学基金(81760751);广西自然科学基金项目(2021GXNSFAA075020);柳州市科技计划项目(2020NBAB0815);柳州市人民医院引进高层次人才科研启动基金项目(LRYGCC202104)。

摘　　要：转化生长因子-β(TGF-β)作为一类调节细胞增殖、生长和分化的细胞因子,参与稳态平衡、组织修复、免疫炎症和细胞外基质重塑等病理生理过程。微RNA(miRNA)是一种短链非编码RNA,通过阻断翻译过程或诱导靶信使RNA降解等方式在转录后环节调控基因的表达。TGF-β信号转导参与肝脏疾病的始终,与非酒精性脂肪性肝病、肝炎、肝纤维化和肝癌等慢性肝脏疾病联系密切,miRNA通过调控TGF-β信号转导影响肝脏疾病的发生发展。因此,探讨miRNA调控TGF-β信号通路在肝脏疾病中的作用可为临床防治肝脏疾病提供新思路。Transforming growth factor-β(TGF-β),as a kind of cytokine regulating cell proliferation,growth and differentiation,is involved in a variety of physiological and pathological processes such as homeostasis,tissue repair,immune inflammation and extracellular matrix remodeling.MicroRNA(miRNA)are short non-coding RNAs that regulate gene expression in the post-transcriptional phase by blocking translation or inducing target messenger RNA degradation.TGF-βsignaling is throughout involved in liver disease and is closely associated with a variety of chronic liver diseases such as non-alcoholic fatty liver disease,hepatitis,liver fibrosis and liver cancer.miRNA affects the occurrence and development of liver diseases by regulating TGF-βsignaling.Therefore,exploring the role of miRNA in regulating TGF-βsignaling pathway in liver diseases,can provide new ideas for the clinical prevention and treatment of liver diseases.

关 键 词：肝脏疾病 微RNA 转化生长因子-β信号通路 

分 类 号：R575[医药卫生—消化系统]