YTH结构域家族蛋白在结直肠癌中的研究进展  

Research Progress of YTH Domain Family Protein in Colorectal Cancer

作　　者：周善一 姚添 张皓凡 马列 贾天航 黄河[1] ZHOU Shanyi;YAO Tian;ZHANG Haofan;MA Lie;JIA Tianhang;HUANG He(Department of Gastrointestinal Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院胃肠外科,太原030001

出　　处：《医学综述》2023年第16期3183-3189,共7页Medical Recapitulate

摘　　要：N^(6)-甲基腺嘌呤(m^(6)A)甲基化修饰通过调控修饰RNA广泛参与多种生物学行为,其与结直肠癌的发生、发展、预后和治疗密切相关。YTH结构域家族蛋白(YTHDF)作为研究最深入的m^(6)A阅读蛋白,通过调控甲基化的RNA影响结直肠癌的进展。部分YTHDF分子通过调控肿瘤相关通路促进结直肠癌进展,而其他YTHDF分子可能抑制结直肠癌进展,且不同研究对同一种YTHDF分子的结论也不同。未来深入研究YTHDF作为新的肿瘤标志物的潜力将为结直肠癌的诊疗提供新思路。N^(6)-methyladenosine(m^(6)A)methylation modification,which regulates modified RNA,is widely involved in various biological processes and closely associated with the occurrence,development,prognosis,and treatment of colorectal cancer.YTH domain family protein(YTHDF),as the most extensively studied m^(6)A reader proteins,exert an influence on the progression of colorectal cancer by regulating methylated RNA.Some YTHDF molecules promote the progression of colorectal cancer by regulating tumor-related pathways,while others may inhibit its progression.Moreover,different studies have yielded different conclusions regarding the same YTHDF molecule.Further research on the potential of YTHDF as a novel tumor biomarker holds promise for providing new insights into the diagnosis and treatment of colorectal cancer.

关 键 词：结直肠癌 YTH结构域家族蛋白 N^(6)-甲基腺嘌呤甲基化 

分 类 号：R735.3[医药卫生—肿瘤]