肠道菌群在肠易激综合征伴焦虑抑郁状态中的研究进展  

Research Progress of Intestinal Flora in Irritable Bowel Syndrome with Anxiety and Depression

作　　者：陶颖 汤丽平[1] TAO Ying;TANG Liping(Department of Gastroenterology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016

出　　处：《医学综述》2023年第18期3674-3678,3683,共6页Medical Recapitulate

基　　金：重庆市科卫联合医学科研项目(2021MSXM325)。

摘　　要：肠易激综合征(IBS)是一种胃肠道功能紊乱的慢性疾病,IBS患者常合并焦虑和(或)抑郁,其长期生活质量及预后在很大程度上受到患者心理状态的影响。IBS与焦虑、抑郁之间的高共患率的基础可能是微生物-肠-脑轴功能紊乱。IBS患者与焦虑抑郁患者具有相似的肠道菌群改变,肠道菌群的组成改变被认为是IBS伴焦虑抑郁状态合并症的发病机制及治疗的关键,肠道菌群可通过神经、免疫、内分泌等途径与大脑进行信号交流,因此针对微生物-肠-脑轴功能紊乱的治疗也越来越受到重视。Irritable bowel syndrome(IBS)is a chronic disease with gastrointestinal dysfunction.Patients with IBS are often complicated with anxiety and/or depression,and the psychological status affects the long-term quality of life and prognosis of the patients with IBS to a great extent.The high comorbidity rate of IBS and anxiety and depression might be based on microbial-gut-brain axis dysfunction.IBS patients and patients with anxiety and depression have similar intestinal flora changes,and the composition of intestinal flora is considered to be the key of the pathogenesis and treatment of IBS with anxiety and depression.Intestinal flora can communicate with the brain through nervous,immune,endocrine pathways etc.,so more and more attention has been paid to the targeted therapy of microbial-gut-brain axis dysfunction.

关 键 词：肠易激综合征 焦虑 抑郁 肠道菌群 微生物-肠-脑轴 

分 类 号：R57[医药卫生—消化系统]