三型固有淋巴细胞在肠道免疫中的作用研究进展  

Research Progress in Role of Group 3 Innate Lymphoid Cell in Intestinal Immunity

作　　者：黄冕 周艳[2] 杨豪杰[1] 干丹 崔灿[1] 王振宜[1] HUANG Mian;ZHOU Yan;YANG Haojie;GAN Dan;CUI Can;WANG Zhenyi(Department of Coloproctology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Geriatrics,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院肛肠科,上海200437 [2]上海交通大学医学院附属仁济医院老年科,上海200127

出　　处：《医学综述》2023年第17期3334-3338,共5页Medical Recapitulate

基　　金：国家自然科学基金(81973859);上海市青年科技英才扬帆计划(20YF1450600);上海市卫生健康委员会中医药科研项目(2020JQ006);上海中医药大学附属岳阳中西医结合医院青年孵育项目(2019YYQ26)。

摘　　要：肠道免疫在机体免疫中十分重要。目前认为,肠道免疫与固有淋巴细胞(ILC)密切相关,ILC可抑制免疫反应,维持组织稳态,且不同类型ILC之间可以互相转换,但受到多方面因素的限制,其中3型ILC(ILC3)主要分布在肠道固有层,其调节肠道免疫的机制可能涉及与树突状细胞、巨噬细胞、T细胞等免疫细胞之间的相互作用、ILC3与肠道菌群的相互调节、ILC3调节肠道生物节律等方面。ILC3在肠道疾病中发挥多种作用,如控制肠道炎症、诱导糖基化、止血、维持肠道稳态等,探索ILC3在肠道免疫中的作用将为肠道疾病治疗提供新的靶点。Intestinal immunity is very important in organism immunity.At present,it is believed that intestinal immunity is closely related to innate lymphoid cell(ILC).ILC can inhibit immune response and maintain tissue homeostasis,and different types of ILC can be converted from each other,but they are limited by many factors.Group 3 ILC(ILC3)are mainly distributing in the intestinal lamina propria.The mechanism of ILC3 regulation of intestinal immunity may involve its interaction with dendritic cells,macrophages,T cells and other immune cells the mutual regulation between ILC3 and intestinal flora,and the regulation of gut rhythm by ILC3.In intestinal diseases,ILC3 can exert various effects,such as controlling intestinal inflammation,inducing glycosylation,hemostasis and maintaining intestinal homeostasis.Exploring the role of ILC3 in intestinal immunity will provide a new target for the treatment of intestinal diseases.

关 键 词：肠道疾病 三型固有淋巴细胞 肠道免疫 肠道菌群 肠道生物节律 

分 类 号：R574[医药卫生—消化系统]