参数全局耦合的基因调控网络建模研究  

Modeling Gene Regulatory Networks with Global Coupling Parameters

作　　者：马梦宇 孙家祥 胡春玲[2] MA Mengyu;SUN Jiaxiang;HU Chunling(Department of Electronic Information Engineering,Anhui Jianzhu University,Hefei 230601,China;Department of Artificial Intelligence and Big Data,Hefei University,Hefei 230601,China)

机构地区：[1]安徽建筑大学电子与信息工程学院,合肥230601 [2]合肥学院人工智能与大数据学院,合肥230601

出　　处：《计算机科学》2023年第S02期126-132,共7页Computer Science

基　　金：合肥市自然科学基金项目(2021035);国家面上基金项目(61976077)。

摘　　要：系统生物学中,基于隐马尔可夫模型的非齐次动态贝叶斯网络(HMM-DBN)能够合理推断出周期性基因表达数据中的调控关系,是重构基因调控网络的重要方法之一。但其通常假设调控参数具有完全独立性(每个时间段的参数需要独立推断),而参数假设(完全独立)等于忽略了自然界生物进化过程的连续性,这会影响网络重构精度。针对上述问题,结合多变点过程,提出了参数全局耦合的HMM-DBN(GCHMM-DBN)。GCHMM-DBN模型通过在HMM-DBN的基础上增加了全局耦合超参数,在所有时间段中共享具有相似高斯分布的噪声方差超参数和信噪比超参数,实现了回归参数的全局耦合,最终提高了基因调控网络的重构精度。在酿酒酵母(酵母)数据集和合成RAF数据集上进行实验,结果表明,与经典的同类型HMM-DBN模型相比,GCHMM-DBN模型拥有更高的基因调控网络重构精度。In systems biology,the hidden Markov model non-homogeneous dynamic Bayesian network(HMM-DBN)can reasonably infer the regulatory relationships in periodic gene expression data and is one of the important methods to reconstruct gene regulatory networks.But it usually assumes complete independence of its regulatory parameters(the parameters of each time periods need to be inferred independently),and the parameter assumption(complete independence)is equivalent to ignore the continuity of biological evolutionary processes in nature,which affects the accuracy of network reconstruction.Aiming at the above problems and combining multiple changepoint processes,a hidden Markov model non-homogeneous dynamic Bayesian network with global coupling of parameters(GCHMM-DBN)is proposed.The GCHMM-DBN model achieves the global coupling of regression parameters by adding the global coupling hyperparameters,sharing the noise variance hyperparameters and signal-to-noise ratio hyperparameters of all time periods in the similarity Gaussian distribution based on the HMM-DBN,and finally improving the reconstruction accuracy of the gene regulation network.Experimental results on Saccharomyces cerevisiae(yeast)and synthetic RAF datasets show that the GCHMM-DBN model has higher accuracy of gene regulatory network reconstruction compared with the classical HMM-DBN model.

关 键 词：动态贝叶斯网络 基因调控网络 全局耦合 非齐次 MCMC 

分 类 号：TP311[自动化与计算机技术—计算机软件与理论]