SIRT1信号通路在中枢神经系统损伤中对神经元的调节作用  

Regulation of SIRT1 Signaling Pathway on Neurons in Central Nervous System Injury

作　　者：王淳 叶润发 金梅花 吕鹏飞 韩东河 WANG Chun;YE Runfa;JIN Meihua;LYU Pengfei;HAN Donghe(College of Medicine,Dalian University,Dalian 116622,China;College of Basic Medicine,Jinzhou Medical University,Jinzhou 121001,China)

机构地区：[1]大连大学医学院,辽宁大连116622 [2]锦州医科大学基础医学院,辽宁锦州121001

出　　处：《医学综述》2022年第20期3972-3977,共6页Medical Recapitulate

基　　金：辽宁省教育厅科学研究经费项目(LJKZ1187);大连市科技创新基金项目(2020JJ27SN093)。

摘　　要：中枢神经系统(CNS)损伤,尤其是各种原因引起的神经元损伤和丢失是导致运动和认知障碍的根本原因。由于神经元难以再生,如何减轻神经元的损伤和凋亡成为CNS损伤后修复的难点。沉默信息调节因子1(SIRT1)是一种广泛表达于多种组织的脱乙酰化酶,能够通过多种信号通路调节炎症浸润、氧化应激、自噬,从而减轻神经元的凋亡,与阿尔茨海默病、创伤性脑损伤等CNS损伤疾病关系密切。因此,探究SIRT1在CNS损伤过程中对神经元的调节作用及相关信号通路可为研究CNS损伤修复提供理论参考。Central nervous system(CNS)injury,especially neuron injury and loss caused by various causes,is the fundamental cause of motor and cognitive impairment.Since neurons are difficult to regenerate,how to reduce neuron injury and apoptosis becomes the difficulty of repair after CNS injury.Silencing information regulator 1(SIRT1)is a deacetylase widely expressed in a variety of tissues,and can regulate inflammatory infiltration,oxidative stress and autophagy through a variety of signaling pathways to reduce neuronal apoptosis,which is closely related to Alzheimer′s disease,traumatic brain injury and other CNS injury diseases.Therefore,the exploration of regulation of SIRT1 on neurons and related signaling pathways in the process of CNS injury can provide theoretical reference for the study of CNS injury repair.

关 键 词：中枢神经系统损伤 沉默信息调节因子1 凋亡 树突棘 突触 

分 类 号：R741.02[医药卫生—神经病学与精神病学]