重视肿瘤相关性肌肉减少症  

Focus on tumour-associated sarcopenia

作　　者：李增宁[1] 常亚平 Li Zengning;Chang Yaping(Department of Nutrition The First Hospital of Hebei Medical University Key Laboratory of Nutrition and Health,Shijiazhuang 050051 Hebei China)

机构地区：[1]河北医科大学第一医院营养科,河北省营养与健康重点实验室,河北石家庄050051

出　　处：《肿瘤代谢与营养电子杂志》2023年第5期573-578,I0002,共7页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：河北省重点研发计划项目(21377728D)。

摘　　要：肿瘤患者由于疾病引起进食不足、高代谢状态,进而引起骨骼肌蛋白质加速分解和蛋白质合成不足,这种肌肉减少症,称为肿瘤相关性肌肉减少症。肌肉减少症具有降低临床疗效、影响精神状况以及增加患者住院费用等危害。重视肿瘤相关性肌肉减少症的核心是对肿瘤患者的肌肉减少症进行筛查、诊断和干预,进而提高临床疗效,缩短住院时间。简易五项评分问卷作为筛查工具,结合计算机断层扫描、磁共振成像或双能X线吸收法等诊断技术,便于及早发现肿瘤患者的肌肉减少症问题。干预手段主要包括营养干预、运动干预和综合干预。其中,营养干预的内容主要包括补充蛋白质、ω-3多不饱和脂肪酸、维生素D等。希望临床上更多的肿瘤相关医务人员以及患者提高对肿瘤相关肌肉减少症的认识、深入进行相关基础研究以及完善精准营养干预措施,从而降低肿瘤患者肌肉减少症的发病风险,从而帮助更多的肿瘤患者。In oncology patients disease-induced hypophagia and hypermetabolism which in turn causes accelerated protein breakdown and insufficient protein synthesis in skeletal muscle is known as tumour-associated sarcopenia.Sarcopenia has the potential to reduce clinical outcomes affect mental status and increase hospitalisation costs.The core of the focus on tumour-associated sarcopenia is to screen diagnose and intervene in oncology patients with sarcopenia thereby improving clinical outcomes and shortening hospital stays.The SARC-F can be used as a screening tool in combination with diagnostic techniques such as computed tomography CT magnetic resonance imaging MRI or dual energy x-ray absorptiometry DXA.Diagnostic techniques such as MRI or DXA facilitate early detection of sarcopenia in tumour patients.Interventions mainly include nutritional interventions exercise interventions and comprehensive interventions.Among them nutritional interventions mainly include supplementation of proteinω-3 polyunsaturated fatty acidsω-3 PUFAs vitamin D and so on.It is hoped that more oncology-related medical personnel and patients will improve their understanding of tumour-related sarcopenia conduct in-depth basic research and improve precise nutritional interventions so as to reduce the risk of sarcopenia in oncology patients and thus help more oncology patients.

关 键 词：肿瘤相关性肌肉减少症 肿瘤 肌肉减少症 

分 类 号：R730.5[医药卫生—肿瘤]