Phenolic Profile,Antioxidant,Antihyperlipidemic and Cardiac Risk Preventive Effect of Pigmented Black Rice Variety Chakhao poireiton in High-Fat High-Sugar Induced Rats  

作　　者：Raja CHAKRABORTY Pratap KALITA Saikat SEN 

机构地区：[1]Faculty of Pharmaceutical Science,Assam down town University,Assam 781026,India [2]Institute of Pharmacy,Assam Don Bosco University,Assam 782402,India [3]Pratiksha Institute of Pharmaceutical Sciences,Guwahati,Assam 781026,India

出　　处：《Rice science》2023年第6期641-651,共11页水稻科学（英文版）

基　　金：The authors acknowledge the Department of Biotechnology,Ministry of Science and Technology,Govt.of India,for funding(Grant No.DBT-NER/AGRI/29/2015).

摘　　要：The present study aimed to investigate the hypolipidemic,antioxidant and cardiac risk-suppressing effects of Chakhao poireiton(CP),a GI-tagged pigmented black rice from India.In vitro and ex vivo studies confirmed that whole rice extracts of CP have potent antioxidant,3-hydroxy-3-methylglutaryl-CoA reductase,cholesterol esterase inhibitory,and antilipase effects.An in vivo study was conducted to evaluate the effects of the ethanol extracts of CP on high-fat high-sugar induced hyperlipidemic rats.The ethanol extract significantly ameliorated lipid parameters and liver enzymes to normal.Levels of lactate dehydrogenase,creatine kinase-N-acetyl cysteine,C-reactive protein,and lipoprotein a were significantly lower in the extract-treated groups than those in the disease control group.A marked reduction of ApoB/ApoA1 and other atherogenic indices were observed in extract-treated groups.Twelve phenolic compounds,i.e.rosamarinic acid,gallic acid,protocatechuic acid etc.,were quantified in CP.This study provided the first evidence of the antihyperlipidemic and cardiac risk inhibitory effects of CP,which would be beneficial in preventing and managing hyperlipidemia,associated oxidative stress,and cardiac complications.

关 键 词：ANTIOXIDANT cardiac risk high fat high sugar HYPOLIPIDEMIC phenolic compound pigmented rice whole rice 

分 类 号：S511[农业科学—作物学]