内镜下切除儿童Peutz-Jeghers综合征巨大息肉效果及安全性分析  

Efficacy and safety of endoscopic resection of giant polyps in pediatric patients with Peutz-Jeghers syndrome

作　　者：王凤革[1] 石步云[2] 黄志华[3] 朱珍妮[1] 伍代琴 WANG Fengge;SHI Buyun;HUANG Zhihua;ZHU Zhenni;WU Daiqin(Department of Paediatric Gastroenterology,Maternal and Child Health Hospital of Hubei Province,Wuhan,Hubei 430070,China;Department of Pediatric Intensive Care,Maternal and Child Health Hospital of Hubei Province,Wuhan,Hubei 430070,China;Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

机构地区：[1]湖北省妇幼保健院儿童消化内科,湖北武汉430070 [2]湖北省妇幼保健院儿童重症监护病房,湖北武汉430070 [3]华中科技大学同济医学院附属同济医院儿科学系,湖北武汉430030

出　　处：《临床儿科杂志》2023年第11期820-826,862,共8页Journal of Clinical Pediatrics

基　　金：湖北陈孝平科技发展基金会临床研究基金(No.CXPJJH12000005-07-05)。

摘　　要：目的探讨Peutz-Jeghers综合征(PJS)患儿的临床特点及内镜下切除患儿PJS巨大息肉的有效性及安全性。方法回顾性分析自2019年1月至2022年8月于儿童消化科住院治疗的11例PJS患儿的临床资料。结果患儿首次入院平均年龄为(8.7±3.0)岁,所有患儿均有口唇、指、趾端黑斑(100%)。双气囊小肠镜(DBE)检查16次,2例患儿完成全消化道检查,发现>3 cm息肉共18枚,小肠12枚(66.7%)、胃1枚、结肠5枚,分别于胃镜、DBE、结肠镜下切除。经口小肠镜患儿术后均有咽痛(100%),腹胀2例次,呕吐1例次,迟发性出血1例次,未出现严重并发症。结论DBE可有效清除消化道息肉,对儿童PJS的治疗具有一定安全性。Objective To investigate the clinical characteristics of children with Peutz-Jeghers syndrome(PJS)and the efficacy and safety of endoscopic resection of giant polyposis in children with PJS.Methods The clinical data of 11 children with PJS who were hospitalized in hospital from January 2019 to August 2022 were collected.The number,distribution of polyps detected and resected endoscopically,and operation related complications were retrospectively analyzed.Results The mean age of first visit was(8.7±3.0)years.All patients have hyperpigmentation on their lips,fingers and toes.Sixteen DBE procedures were performed,and total gastrointestinal examinations were conducted in two cases.18 polyps>3 cm were found,including 12 in the small intestine,1 in the stomach and 5 in the colon,all of which were resected under endoscopy.Sore throat happened in all cases who underwent DBE via the oral route,abdominal distension in 2 cases,vomiting in 1 case,delayed bleeding in 1 case,but no serious complications in all cases.Conclusion Gastrointestinal endoscopy,especially DBE,can effectively remove gastrointestinal polyps,is safe and effective for the treatment of pediatric patients with PJS.

关 键 词：PEUTZ-JEGHERS综合征 巨大息肉 双气囊小肠镜 儿童 

分 类 号：R725.9[医药卫生—儿科]