TIPE在多发性骨髓瘤中的表达及临床意义  

Expression and clinical significance of TIPE in multiple myeloma

作　　者：顾珍珠 赵雪芸[1] 徐宁[1] 任秀莲[1] 刘马莲 GU Zhenzhu;ZHAO Xueyun;XU Ning;REN Xiulian;LIU Malian(Department of Hematology,Baotou City Central Hospital,Inner Mongolia,Baotou 014000,China)

机构地区：[1]内蒙古自治区包头市中心医院血液科,内蒙古包头014000

出　　处：《中国医药科学》2023年第19期157-160,共4页China Medicine And Pharmacy

基　　金：内蒙古自治区包头市卫生健康科技计划项目(wsjkkj070)。

摘　　要：目的研究肿瘤坏死因子α诱导蛋白8(TIPE/TNFAIP8)在初诊及不同治疗效果多发性骨髓瘤(MM)患者中的表达,分析其与患者临床指标相关性,探索TIPE在MM中的临床意义。方法选取2021年8月至2022年12月包头市中心医院、内蒙古医科大学第三附属医院血液科收治的MM患者共44例,其中初诊11例、治疗后达完全缓解(CR)/非常好的部分缓解(VGPR)10例、部分缓解(PR)11例、复发12例,另选取缺铁性贫血10例作为对照组。Real-time PCR检测各组患者骨髓细胞中TIPE mRNA相对表达量。分析初诊组TIPE mRNA相对表达量与患者年龄、性别、传统分期系统分期(DS分期)、国际分期系统分期(ISS分期)等临床指标的关系。结果MM初诊组、PR组、复发组中TIPE mRNA的表达均高于CR/VGPR组和对照组(P<0.05);初诊组与复发组比较,CR/VGPR组与对照组TIPE mRNA的表达比较,差异无统计学意义(P>0.05)。CR/VGPR组、PR组及复发组组间TIPE mRNA的表达比较,呈递增趋势,即CR/VGPR组<PR组<复发组,差异有统计学意义(P<0.05)。初诊MM患者DS分期Ⅲ期组TIPE mRNA表达水平较Ⅰ~Ⅱ期组明显增高,差异有统计学意义(P<0.05);不同性别、年龄<60岁和≥60岁、ISS分期Ⅰ~Ⅱ期和Ⅲ期组间比较,差异均无统计学意义(P>0.05)。结论TIPE可能参与MM的发病机制,TIPE的高表达可能与MM更严重的临床DS分期有关。Objective To study the expression of tumor necrosis factor α-induced protein 8(TIPE/TNFAIP8)in newly diagnosed patients with multiple myeloma(MM)with different therapeutic effects,analyze the correlation between TIPE and patients’clinical indexes,and explore the clinical significance of TIPE in MM.Methods A total of 44 patients with MM who were admitted to the Department of Hematology of Baotou City Central Hospital and the Third Affiliated Hospital of Inner Mongolia Medical University from August 2021 to December 2022 were selected.There were 11 patients with initial diagnosis,10 patients with complete response(CR)/very good partial response(VGPR),11 patients with partial response(PR)and 12 patients with relapse.In addition,10 patients with iron deficiency anemia were included in the control group.Real-time PCR was adopted to detect the relative expression of TIPE mRNA in bone marrow cells of patients in each group.The relationship between the relative expression of TIPE mRNA and clinical indicators such as age,gender,DS stage,and ISS stage in the initial diagnosis group were analyzed.Results The TIPE mRNA expression in the initial diagnosis group,the PR group and the relapse group was higher than that in the CR/VGPR group and the control group(P<0.05).There was no significant difference in the TIPE mRNA expression between the initial diagnosis group and the relapse group,or between the CR/VGPR group and the control group(P>0.05).The TIPE mRNA expression in the CR/VGPR group,the PR group and the relapse group showed an increasing trend,i.e.,CR/VGPR group<PR group<relapse group,with statistically significant difference(P<0.05).In the initial diagnosis group,the TIPE mRNA expression in the DS stage Ⅲ subgroup was significantly higher than that in the DS stage Ⅰ-Ⅱ subgroup,with statistically significant difference(P<0.05).There was no significant difference in the TIPE mRNA expression among different sexes,between ages<60 and≥60,or between ISS stages Ⅰ-Ⅱ and Ⅲ(P>0.05).Conclusion TIPE may be involve

关 键 词：多发性骨髓瘤 发病机制 TIPE 临床意义 

分 类 号：R733.3[医药卫生—肿瘤]