脑脊液LDH同工酶比值在脑出血相关的临床意义的研究  

A study of the clinical significance of cerebrospinal fluid LDH isoenzyme ratios in cerebral haemorrhage

作　　者：梁伟杏 程添长 廖小玲 陈宇 林锐 徐永乐 范岳彬 张家畅 LIANG Weixing;CHENG Tianchang;LIAO Xiaoling;CHEN Yu;LIN Rui;XU Yongle;FAN Yuebin;ZHANG Jiachang(Department of Intensive Care Medicine,Zhaoqing Gaoyao District People’s Hospital,Guangdong,Zhaoqing 526040,China;Department of Neurosurgery,Zhaoqing Gaoyao District People’s Hospital,Guangdong,Zhaoqing 526040,China;Department of Laboratory Medicine,Zhaoqing Gaoyao District People’s Hospital,Guangdong,Zhaoqing 526040,China)

机构地区：[1]广东省肇庆市高要区人民医院重症医学科,广东肇庆526040 [2]广东省肇庆市高要区人民医院神经外科,广东肇庆526040 [3]广东省肇庆市高要区人民医院检验科,广东肇庆526040

出　　处：《中国医药科学》2023年第19期165-168,共4页China Medicine And Pharmacy

基　　金：广东省肇庆市科技创新指导类项目(202004031481)。

摘　　要：目的探讨脑脊液乳酸脱氢酶(LDH)同工酶比值(LDH-1/LDH-2)在急性脑出血患者中的临床意义及诊疗价值。方法选取2020年1—12月肇庆市高要区人民医院收治的100例急性脑出血患者作为观察组,另选取同期体检健康人员50例作为对照组。所有研究对象均进行脑脊液LDH检测,检测指标为LDH-1、LDH-2,并计算LDH-1/LDH-2值,对比不同分组及急性脑出血不同病情患者LDH-1、LDH-2以及LDH-1/LDH-2值的差异,分析其在急性脑出血患者中的检测意义及诊疗价值。结果观察组患者LDH-1以及LDH-1/LDH-2水平均明显高于对照组,差异有统计学意义(P<0.05);急性脑出血患者中,脑干出血患者LDH-1/LDH-2值明显高于其他部位出血,差异有统计学意义(P<0.05),且其他部位出血患者LDH-1/LDH-2值比较,差异无统计学意义(P>0.05);不同意识状态、不同出血量、是否破入脑室以及不同预后的急性脑出血患者LDH-1/LDH-2值比较,差异有统计学意义(P<0.05)。结论急性脑出血患者LDH水平升高程度对脑出血病情严重程度的评估具有重要的提示作用,并且对判定近期预后情况具有一定的临床价值。Objective To investigate the clinical significance and diagnostic value of cerebrospinal fluid lactate dehydrogenase(LDH)isoenzyme ratio(LDH-1/LDH-2)in patients with acute cerebral haemorrhage.Methods A total of 100 cases of acute cerebral haemorrhage patients admitted to the Zhaoqing Gaoyao District People’s Hospital of from January to December 2020 were selected as the experimental group,and another 50 cases of healthy people from the same period of physical examination were selected as the control group.All study subjects underwent cerebrospinal fluid LDH testing for LDH-1 and LDH-2,and LDH-1/LDH-2 values were calculated.The differences in LDH-1,LDH-2 and LDH-1/LDH-2 values in different groups and in patients with different stages of acute cerebral haemorrhage were compared to determine their significance and diagnostic value in patients with acute cerebral haemorrhage.Results LDH-1 and LDH-1/LDH-2 levels were significantly higher in the experimental group than in the control group,with statistically significant differences(P<0.05).Among patients with acute cerebral haemorrhage,LDH-1/LDH-2 values were significantly higher in patients with brain stem haemorrhage than in those with haemorrhage from other sites,with a statistically significant difference(P<0.05).In addition,a comparison of LDH-1/LDH-2 values in patients with bleeding at other sites revealed no statistically significant differences(P>0.05);There was a statistically significant difference in LDH-1/LDH-2 values among patients with acute cerebral haemorrhage with different states of consciousness,different amounts of bleeding,with and without penetration into the ventricles,and with different prognoses(P<0.05).Conclusion The level of elevated LDH in patients with acute cerebral haemorrhage is an important indicator of the severity of cerebral haemorrhage and has clinical value in determining the most recent prognosis.

关 键 词：脑脊液 乳酸脱氢酶 乳酸脱氢酶同工酶比值 急性脑出血 病情程度 

分 类 号：R743.34[医药卫生—神经病学与精神病学]